2007
DOI: 10.1001/archderm.143.12.1536
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A Comparison of Oral Methylprednisolone Plus Azathioprine or Mycophenolate Mofetil for the Treatment of Bullous Pemphigoid

Abstract: To investigate the safety and efficacy of oral methylprednisolone combined with azathioprine sodium or mycophenolate mofetil for the treatment of bullous pemphigoid.Design: A prospective, multicenter, randomized, nonblinded clinical trial to compare 2 parallel groups of patients with bullous pemphigoid undergoing different treatments.Setting: Thirteen departments of dermatology in Germany.Patients: Patients with bullous pemphigoid (n=73) as evidenced by clinical lesions suggestive of bullous pemphigoid, signs … Show more

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Cited by 132 publications
(113 citation statements)
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“…Oral corticosteroids are still used when the application of topical steroid is too difficult. Immunosuppressant agents such as methotrexate or mycophenolate mofetil are prescribed in cases of resistance or dependence to steroids [11,12,13,14]. …”
Section: Introductionmentioning
confidence: 99%
“…Oral corticosteroids are still used when the application of topical steroid is too difficult. Immunosuppressant agents such as methotrexate or mycophenolate mofetil are prescribed in cases of resistance or dependence to steroids [11,12,13,14]. …”
Section: Introductionmentioning
confidence: 99%
“…A range of other systemic treatments such as azathioprine, methotrexate, dapsone, mycophenolate, high-dose intravenous immunoglobulin, plasmapheresis or rituximab have been used for BP that is more severe or unresponsive to first-line treatments such as topical or oral corticosteroids, but, apart from some combination therapies, 56 most have been poorly evaluated. As this study has indicated how conclusions may differ for those with severe disease, future trials should present results according to baseline severity and consider planned subgroup analyses for those with severe disease.…”
Section: Implications For Researchmentioning
confidence: 99%
“…W wyjątkowych przypadkach możliwe jest rozważenie zastosowania poniższych leków, ale ich skuteczność nie została potwierdzona: -azatiopryna -1-2,5 mg/kg m.c./dobę -wskazane badanie stężenia enzymu metabolizującego azatioprynę -tiopurynowej metylotransferazy (TPMT) [59,60], -mykofenolan mofetylu -2 g/dobę lub mykofenolan sodowy 1,44 g/dobę [59,60], -dapson -do 1,5 mg/kg m.c./dobę [61], -cyklofosfamid -1-3 mg/kg m.c./dobę p.o. lub w postaci pulsów i.v.…”
Section: Alternatywne Metody Terapii Ciężkiego Pemfigoiduunclassified
“…W przypadku BP opornego na leczenie miejscowe klobetazolem i terapię prednizonem należy rozważyć metody alternatywne: -metotreksat, azatioprynę, mykofenolan mofetylu [57][58][59][60], -immunoglobuliny dożylne (trzeci stopień wiarygodności) [62], -immunoadsorpcję (czwarty stopień wiarygodności) [63], -leki biologiczne: anty-CD20 (rytuksymab), anty--IgE (omalizumab) (czwarty stopień wiarygodności) [64,65], -cyklofosfamid (trzeci stopień wiarygodności) [51], -wymianę plazmy (pierwszy stopień wiarygodności) [66].…”
Section: Leczenie Opornego Pemfigoidu (Ang Refractory Pemphigoid)unclassified