2014
DOI: 10.1007/s11357-014-9637-0
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Abstract: Cellular senescence is a stable proliferation arrest associated with an altered secretory pathway, the senescence-associated secretory phenotype. However, cellular senescence is initiated by diverse molecular triggers, such as activated oncogenes and shortened telomeres, and is associated with varied and complex physiological endpoints, such as tumor suppression and tissue aging. The extent to which distinct triggers activate divergent modes of senescence that might be associated with different physiological e… Show more

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Cited by 45 publications
(37 citation statements)
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“…Furthermore, derepression of hTERT transcription is a process that develops over time, because hTERT transcripts, protein, and activity can be detected at the earliest only after ∼1 mo in OIS. Supporting this interpretation are data demonstrating absence of increased hTERT expression at time points earlier than 30 d (38), which is consistent with our data. Our results therefore suggest that the chromatin landscape in cells that had undergone OIS is constantly changing, thereby placing these cells at risk for escaping an otherwise stable proliferative arrest.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Furthermore, derepression of hTERT transcription is a process that develops over time, because hTERT transcripts, protein, and activity can be detected at the earliest only after ∼1 mo in OIS. Supporting this interpretation are data demonstrating absence of increased hTERT expression at time points earlier than 30 d (38), which is consistent with our data. Our results therefore suggest that the chromatin landscape in cells that had undergone OIS is constantly changing, thereby placing these cells at risk for escaping an otherwise stable proliferative arrest.…”
Section: Discussionsupporting
confidence: 92%
“…Significantly, signaling through the Ras/B-Raf MAP kinase pathway increases c-Myc protein levels, not only by suppressing its degradation (35,36), but also by promoting c-Myc gene expression (37). Surprisingly, yet consistent with our data, c-Myc mRNA levels remain elevated in human cells that had undergone H-Ras G12V -induced senescence, despite their exit from the cell-division cycle (38). Cells that had undergone H-Ras G12V -and B-Raf V600E -induced senescence therefore continuously synthesize a transcription factor capable of promoting hTERT gene expression.…”
Section: Discussionsupporting
confidence: 87%
“…15 Finally, while both OIS and TDIS induce secretion of myriad cytokines and other factors as part of the senescence-associated secretory phenotype (SASP), the SASP differs both in magnitude and composition between these 2 modes of senescence.…”
Section: Introductionmentioning
confidence: 99%
“…NF90 is also involved in DNA break repair, which supports this hypothesis (41). Moreover, a recent study compared gene expression levels between replicative and oncogene-induced senescence (42). In this study, gene set enrichment analysis showed that the gene ontology sets most enriched in replicative senescence included "Extracellular structure organization & biogenesis," "Synapse organization & biogenesis," "Female pregnancy," "Synaptogenesis," and "Hematopoietin interferon class D2000 cytokine receptor activity," but none is scored highly in oncogene-induced senescence.…”
Section: Discussionmentioning
confidence: 58%