A COMPARISON OF LOW DOSE LEVAMISOLE and PENICILLAMINE IN RHEUMATOID ARTHRITIS

Clemens, Laurence; Ansell, Barbara M.; Bernstein, R. M.; Hall, M A; McCauley, Dayna L.

doi:10.1111/j.1445-5994.1983.tb02607.x

Cited by 2 publications

(17 citation statements)

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“…A total of 29 interventions among 132 randomized clinical trials (RCTs) represented by 130 publications (mean [range], 71.0% [27.0%-100%] females in studies; mean [range] of ages in studies, 53 [36-70] years) were identified, which included 13 260 patients with rheumatoid arthritis. The number of studies with measured outcomes was 118 studies for TJC, 116 studies…”

Section: Resultsmentioning

confidence: 99%

“…Figure 1 shows a flowchart of the identification of the pool of RCTs. We included 131 publications, which represented 133 studies. In 1 study, the 2 interventions (sulfapyridine and 5-aminosalicylic acid) were not connected to the network.…”

Section: Resultsmentioning

confidence: 99%

“…In 1 study, the 2 interventions (sulfapyridine and 5-aminosalicylic acid) were not connected to the network. The remaining 132 studies were included in the NMA. In the post hoc screening in PubMed on September 15, 2022, we did not identify relevant studies (eResults 1 in Supplement 1).…”

Section: Resultsmentioning

confidence: 99%

“…The network comprises 27 mono-DMARD groups (methotrexate, peroral; sulfasalazine; leflunomide; cyclosporine; gold, injectable; chloroquine/hydroxychloroquine; D-penicillamine; azathioprine; gold, peroral; cyclophosphamide; levamisole; tacrolimus; Tripterygium wilfordii ; iguratimod; timegadine; bucillamine; tiopronin; pyritinol; mycophenolate; OM-8980; lobenzarit; rheumacon; prospidin; aminopterin; eazmov plus; dapsone9; and methotrexate, injectable), 1 GC group, and 1 p...…”

Section: Resultsmentioning

confidence: 99%

“…For our primary analysis of all 132 studies (represented by 130 publications) we used the most frequently reported outcome, TJC. This included imputed TJC values for studies that did not measure TJC (eMethods 5 in Supplement 1), denominated TJCi.…”

Section: Methodsmentioning

confidence: 99%

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Monotreatment With Conventional Antirheumatic Drugs or Glucocorticoids in Rheumatoid Arthritis

Guski,

Jürgens,

Pedder

et al. 2023

JAMA Netw Open

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ImportanceThis is the first network meta-analysis to assess outcomes associated with multiple conventional synthetic disease-modifying antirheumatic drugs and glucocorticoid.ObjectiveTo analyze clinical outcomes after treatment with conventional synthetic disease-modifying antirheumatic drugs and glucocorticoid among patients with rheumatoid arthritis.Data SourcesWith no time restraint, English language articles were searched in MEDLINE, Embase, Cochrane Central, ClinicalTrials.gov, and reference lists of relevant meta-analyses until September 15, 2022.Study SelectionFour reviewers in pairs of 2 independently included controlled studies randomizing patients with rheumatoid arthritis to mono–conventional synthetic disease-modifying antirheumatic drugs, glucocorticoid, placebo, or nonactive treatment that recorded at least 1 outcome of tender joint count, swollen joint count, erythrocyte sedimentation rate, and C-reactive protein level. Of 1098 assessed articles, 130 articles (132 interventions) were included.Data Extraction and SynthesisThe review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guideline, and data quality was assessed by the Cochrane risk of bias tool RoB 2. Data were extracted by a single author and checked independently by 2 authors. Data were analyzed using a random effect model, and data analysis was conducted from June 2021 to February 2023.Main Outcomes and MeasuresA protocol with hypothesis and study plan was registered before data recording. The most complete of recorded outcomes (tender joint count) was used as primary outcome, with imputations based on other outcomes to obtain a full analysis of all studies. Absolute change adjusted for baseline disease activity was assessed.ResultsA total of 29 interventions in 275 treatment groups among 132 randomized clinical trials (mean [range], 71.0% [27.0% to 100%] females in studies; mean [range] of ages in studies, 53 [36 to 70] years) were identified, which included 13 260 patients with rheumatoid arthritis. The mean (range) duration of RA was 79 (2 to 243) months, and the mean (range) disease activity score was 6.3 (4.0 to 8.8). Compared with placebo, oral methotrexate was associated with a reduced tender joint count by 5.18 joints (95% credible interval [CrI], 4.07 to 6.28 joints). Compared with methotrexate, glucocorticoid (−2.54 joints; 95% CrI, −5.16 to 0.08 joints) and remaining drugs except cyclophosphamide (6.08 joints; 95% CrI, 0.44 to 11.66 joints) were associated with similar or lower tender joint counts.Conclusions and RelevanceThis study’s results support the present role of methotrexate as the primary reference conventional synthetic disease-modifying antirheumatic drug.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%