A comparison of four methods to estimate dim light melatonin onset: a repeatability and agreement study

Glacet, Raphaëlle; Reynaud, Ève; Robin-Choteau, Ludivine; Reix, Nathalie; Hugueny, Laurence; Ruppert, Élisabeth; Geoffroy, Pierre A.; Kilic-Huck, Ülker; Comtet, Henri; Bourgin, Patrice

doi:10.1080/07420528.2022.2150554

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…This indicates that the HC-LED lighting environment with a regulated wavelength of 480 nm can be more favorable for nocturnal melatonin secretion than the c-LED lighting environment. As documented in many previous studies, light-induced melatonin control is not new; however, an obvious difference between the protocol used in the previous studies related to circadian rhythm such as research on melatonin and core body temperature (CBT), the CR is performed in a semirecumbent posture under a dim light condition for at least 24 h to minimize external influences. − ,− Instead of this CR phase, the present study set up an acclimation phase for approximately 1 day under the same light environment as the specified protocol. Nevertheless, the significant difference in melatonin levels according to the lighting environment shows that melatonin can be controlled by indoor lighting in a regular and habitual routine.…”

Section: Resultsmentioning

confidence: 99%

Development and Verification of a 480 nm Blue Light Enhanced/Reduced Human-Centric LED for Light-Induced Melatonin Concentration Control

Eo,

Choi,

Kim

et al. 2023

ACS Omega

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Section: Resultsmentioning

confidence: 99%

Development and Verification of a 480 nm Blue Light Enhanced/Reduced Human-Centric LED for Light-Induced Melatonin Concentration Control

Eo,

Choi,

Kim

et al. 2023

ACS Omega

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“…In older adults with varying risks for dementia, increased light exposure in the evening results in earlier dim light melatonin onset (DLMO) time. This shift in the circadian phase may disturb rhythmicity that is often associated with dementia [ 486 , 487 , 488 ].…”

Section: Discussionmentioning

confidence: 99%

Light, Water, and Melatonin: The Synergistic Regulation of Phase Separation in Dementia

Loh¹,

Reíter

2023

IJMS

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The swift rise in acceptance of molecular principles defining phase separation by a broad array of scientific disciplines is shadowed by increasing discoveries linking phase separation to pathological aggregations associated with numerous neurodegenerative disorders, including Alzheimer’s disease, that contribute to dementia. Phase separation is powered by multivalent macromolecular interactions. Importantly, the release of water molecules from protein hydration shells into bulk creates entropic gains that promote phase separation and the subsequent generation of insoluble cytotoxic aggregates that drive healthy brain cells into diseased states. Higher viscosity in interfacial waters and limited hydration in interiors of biomolecular condensates facilitate phase separation. Light, water, and melatonin constitute an ancient synergy that ensures adequate protein hydration to prevent aberrant phase separation. The 670 nm visible red wavelength found in sunlight and employed in photobiomodulation reduces interfacial and mitochondrial matrix viscosity to enhance ATP production via increasing ATP synthase motor efficiency. Melatonin is a potent antioxidant that lowers viscosity to increase ATP by scavenging excess reactive oxygen species and free radicals. Reduced viscosity by light and melatonin elevates the availability of free water molecules that allow melatonin to adopt favorable conformations that enhance intrinsic features, including binding interactions with adenosine that reinforces the adenosine moiety effect of ATP responsible for preventing water removal that causes hydrophobic collapse and aggregation in phase separation. Precise recalibration of interspecies melatonin dosages that account for differences in metabolic rates and bioavailability will ensure the efficacious reinstatement of the once-powerful ancient synergy between light, water, and melatonin in a modern world.

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“…“Thanks to its objective nature, the hockey stick method may provide better estimates than the mean of the visual estimations of several raters. These findings suggest that the hockey stick method provides the most reliable estimate of DLMO within the tested methods and should be considered for use in future studies.” [ 13 ]…”

mentioning

confidence: 99%

Obituary for Dr. Konstantin Danilenko (19.03.1962–18.01.2023)

Putilov

2023

Clocks & Sleep

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A comparison of four methods to estimate dim light melatonin onset: a repeatability and agreement study

Cited by 4 publications

References 28 publications

Development and Verification of a 480 nm Blue Light Enhanced/Reduced Human-Centric LED for Light-Induced Melatonin Concentration Control

Development and Verification of a 480 nm Blue Light Enhanced/Reduced Human-Centric LED for Light-Induced Melatonin Concentration Control

Light, Water, and Melatonin: The Synergistic Regulation of Phase Separation in Dementia

Obituary for Dr. Konstantin Danilenko (19.03.1962–18.01.2023)

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