A comparison of colorimetric versus fluorometric sentinel lymph node mapping during robotic surgery for endometrial cancer

Sinno, Abdulrahman K.; Fader, Amanda N.; Roche, Kara Long; Giuntoli, Robert L.; Tanner, Edward J.

doi:10.1016/j.ygyno.2014.05.022

Cited by 138 publications

(96 citation statements)

References 32 publications

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“…The optimal tracer injection site for endometrial cancer has been investigated and reported from several observational studies (Tables 1 and 2) [30,32,35–58]. Sub-serosal uterine fundus, deeper myometrium [59,60] and hysteroscopically guided sub-endometrial tumor injections have been evaluated [49,61].…”

Section: Introductionmentioning

confidence: 99%

Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations

Holloway

Abu‐Rustum

Backes

et al. 2017

Gynecologic Oncology

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335

287

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The emphasis in contemporary medical oncology has been “precision” or “personalized” medicine, terms that imply a strategy to improve efficacy through targeted therapies. Similar attempts at precision are occurring in surgical oncology. Sentinel lymph node (SLN) mapping has recently been introduced into the surgical staging of endometrial cancer with the goal to reduce morbidity associated with comprehensive lymphadenectomy, yet obtain prognostic information from lymph node status. The Society of Gynecologic Oncology’s (SGO) Clinical Practice Committee and SLN Working Group reviewed the current literature for preparation of this document. Literature-based recommendations for the inclusion of SLN assessment in the treatment of patients with endometrial cancer are presented. This article examines: History and various techniques of SLN mapping in endometrial cancerPathology and clinical outcomes from SLN assessmentControversies and future directions for research in SLN assessment in endometrial cancer

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Section: Introductionmentioning

confidence: 99%

Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations

Holloway

Abu‐Rustum

Backes

et al. 2017

Gynecologic Oncology

Self Cite

335

287

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“…At present, the use of green indocyanine (ICG) seems to offer better results in terms of overall and bilateral detection rate [18][19][20]. But what are the reasons for the methods failure?…”

Section: Introductionmentioning

confidence: 99%

Sentinel Lymph Node Biopsy in the Treatment of Endometrial Cancer: Why We Fail? Results of a Prospective Multicenter Study on the Factors Associated with Failure of Node Mapping with Indocyanine Green

Ianieri

Puppo²,

Novelli³

et al. 2019

Gynecol Obstet Invest

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Background: The sentinel lymph node (SLN) mapping for endometrial cancer staging is gaining wide diffusion, but there is no definitive evidence on the factors associated with the failure of mapping. Objectives: To analyze the factors associated with the possible failure of bilateral SLN mapping with indocyanine green (ICG). Methods: A prospective observational study without control on 110 patients with endometrial cancer apparently confined to the uterus, underwent laparoscopic surgical staging with SLN mapping with ICG. Results: Possible risk factors associated with bilateral mapping failure were analyzed, and a multivariate analysis was performed. The bilateral detection rate for SLNs mapping was 72.7%, whereas at least one SLN was detected in 79.1% of patients. No SLNs were identified in 6.3%. None of the patients or features related to tumor were associated with a risk of failure of the method. The only factor analyzed that was significantly associated with the success of bilateral mapping was the surgeon (p = 0.003). Conclusions: Neither obesity nor the presence of lymph node metastases was associated with mapping failure. However, there remains a need for further studies to understand all the mechanisms linked to the unsuccessful method results and to reduce the use of systematic lymphadenectomy in the case of mapping failure.

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“…They found that this technology can help accurately and safely avoid full lymphadenectomies in women with high grade metastatic tumors, thus preventing secondary complications such as lymphedema (124). Previous research has confirmed that combining robotic-assisted hysterectomies with fluorescent sentinel lymph node mapping outperformed colorimetric dyes (125)(126)(127)(128). These studies and their successors have the potential to change the standard of care for endometrial cancer therapy, which as of yet does not have a consensus regarding the utility of sentinel lymph node mapping (124).…”

Section: Fluorescence-assisted Robotic Surgerymentioning

confidence: 99%

Advances in fluorescent-image guided surgery

2016

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A comparison of colorimetric versus fluorometric sentinel lymph node mapping during robotic surgery for endometrial cancer

Cited by 138 publications

References 32 publications

Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations

Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations

Sentinel Lymph Node Biopsy in the Treatment of Endometrial Cancer: Why We Fail? Results of a Prospective Multicenter Study on the Factors Associated with Failure of Node Mapping with Indocyanine Green

Advances in fluorescent-image guided surgery

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