A comparative study on the effects of tetracyclines and lithium on the cyclic amp second messenger system in rat brain

cAMP induction by ouabain promotes endothelin-1 secretion via MAPK/ERK signaling in beating rabbit atria

“…In the presence of the AC activator forskolin, ouabain further elevated atrial cAMP production. These findings are similar to those that ouabain increases intracellular cAMP production in the intestinal mucosa, pancreatic islets, and brain by stimulating AC [ 13 17 18 ].…”

cAMP induction by ouabain promotes endothelin-1 secretion via MAPK/ERK signaling in beating rabbit atria

“…In the presence of the AC activator forskolin, ouabain further elevated atrial cAMP production. These findings are similar to those that ouabain increases intracellular cAMP production in the intestinal mucosa, pancreatic islets, and brain by stimulating AC [ 13 17 18 ].…”

Development of Lithium-Induced Nephrogenic Diabetes Insipidus Is Dissociated from Adenylyl Cyclase Activity

“…Also, lithium treatment for Ͼ1 wk reduced receptor-mediated cAMP formation through inhibition of a Ca 2ϩ /calmodulin-sensitive adenylyl cyclase and diminished phosphorylation of the CREB transcription factor in brain tissue and cells (2,45,46). As such, our data that the onset of lithium-induced NDI is cAMP independent might not be of relevance to the brain.…”

Ouabain-induced stimulation of sodium-hydrogen exchange in rat optic nerve astrocytes

“…Such a cAMP rise has been reported in different tissues, including dog renal cortex (53), goldfish intestinal mucosa (2), mouse pancreatic islets (21), murine epithelioid and fibroblastic cell lines (34), rat brain (38), and rat renal collecting tubule cells in culture (28). In each of these reported studies, the concentration of ouabain was likely enough to inhibit Na-K-ATPase to a degree where cytoplasmic sodium increased.…”

cAMP induction by ouabain promotes endothelin-1 secretion via MAPK/ERK signaling in beating rabbit atria

“…In the presence of the AC activator forskolin, ouabain further elevated atrial cAMP production. These findings are similar to those that ouabain increases intracellular cAMP production in the intestinal mucosa, pancreatic islets, and brain by stimulating AC [ 13 17 18 ].…”

Development of Lithium-Induced Nephrogenic Diabetes Insipidus Is Dissociated from Adenylyl Cyclase Activity

“…Also, lithium treatment for Ͼ1 wk reduced receptor-mediated cAMP formation through inhibition of a Ca 2ϩ /calmodulin-sensitive adenylyl cyclase and diminished phosphorylation of the CREB transcription factor in brain tissue and cells (2,45,46). As such, our data that the onset of lithium-induced NDI is cAMP independent might not be of relevance to the brain.…”

Ouabain-induced stimulation of sodium-hydrogen exchange in rat optic nerve astrocytes

“…Such a cAMP rise has been reported in different tissues, including dog renal cortex (53), goldfish intestinal mucosa (2), mouse pancreatic islets (21), murine epithelioid and fibroblastic cell lines (34), rat brain (38), and rat renal collecting tubule cells in culture (28). In each of these reported studies, the concentration of ouabain was likely enough to inhibit Na-K-ATPase to a degree where cytoplasmic sodium increased.…”

cAMP induction by ouabain promotes endothelin-1 secretion via MAPK/ERK signaling in beating rabbit atria

“…In the presence of the AC activator forskolin, ouabain further elevated atrial cAMP production. These findings are similar to those that ouabain increases intracellular cAMP production in the intestinal mucosa, pancreatic islets, and brain by stimulating AC [ 13 17 18 ].…”

Development of Lithium-Induced Nephrogenic Diabetes Insipidus Is Dissociated from Adenylyl Cyclase Activity

“…Also, lithium treatment for Ͼ1 wk reduced receptor-mediated cAMP formation through inhibition of a Ca 2ϩ /calmodulin-sensitive adenylyl cyclase and diminished phosphorylation of the CREB transcription factor in brain tissue and cells (2,45,46). As such, our data that the onset of lithium-induced NDI is cAMP independent might not be of relevance to the brain.…”

Ouabain-induced stimulation of sodium-hydrogen exchange in rat optic nerve astrocytes

“…Such a cAMP rise has been reported in different tissues, including dog renal cortex (53), goldfish intestinal mucosa (2), mouse pancreatic islets (21), murine epithelioid and fibroblastic cell lines (34), rat brain (38), and rat renal collecting tubule cells in culture (28). In each of these reported studies, the concentration of ouabain was likely enough to inhibit Na-K-ATPase to a degree where cytoplasmic sodium increased.…”