High x-ray radiation dose is a major public concern with the increasing use of multidetector computed tomography (CT) for diagnosis of cardiovascular diseases. This issue must be effectively addressed by dose-reduction techniques. Recently, our group proved that an internal region of interest (ROI) can be exactly reconstructed solely from localized projections if a small subregion within the ROI is known. In this article, we propose to use attenuation values of the blood in aorta and vertebral bone to serve as the known information for localized cardiac CT. First, we describe a novel interior tomography approach that backprojects differential fan-beam or parallel-beam projections to obtain the Hilbert transform and then reconstructs the original image in an ROI using the iterative projection onto convex sets algorithm. Then, we develop a numerical phantom based on clinical cardiac CT images for simulations. Our results demonstrate that it is feasible to use practical prior information and exactly reconstruct cardiovascular structures only from projection data along x-ray paths through the ROI. Cardiac CT continues evolving with the innovative technologies such as controlled 6,7 and dynamic volumetric cardiac CT. 8,9 The 320-slice MDCTs are now commercially available.
NIH Public AccessInnovative scanning trajectories such as the saddle curve 10 and compositing circles 11 have been proposed. Hence, dramatic progress of CT technology, especially MDCT, is foreseeable in the near future. 12 As a result, its use is likely to improve the diagnosis of CVD, including coronary artery disease, risk factor assessment, and other cardiovascular disease such as congenital heart disease in infant and children.Computed tomography is the largest source of radiation dose in diagnostic imaging. A high dose of ionizing radiation associated with x-rays in CT can damage living cells, whereas the effect of low-level exposure (<100 mSv) remains unclear. It has also been estimated that the cancer risk caused by CT may be up to 1.5% to 2.0%. 13 Current recommendations are to use radiation dose as low as possible while satisfying the diagnosis requirement. Therefore, there is an urgent need for effective dose reduction.Several strategies were proposed to reduce the radiation dose, most of which focused on the modulation of scan parameters, modification of scanner geometry, and use of prospective gating, and so on.14 , 15 Although these methods can reduce the x-ray radiation significantly, further reduction can be made by developing new methods to reduce the amount of raw data. The first landmark work along this direction is the well-known fan-beam half-scan formula. 16 In 2002, Noo et al17 reported a new imaging condition that makes exact and stable reconstruction possible when the object is not truncated in any required fan-beam projections, and all the lines through the region of interest (ROI) intersect with the source trajectory nontangentially. The recent milestone is the 2-step Hilbert transform method,18 which performs the ...