A comparative study of wound dressings loaded with silver sulfadiazine and silver nanoparticles: In vitro and in vivo evaluation

Mina, Mani; Shamloo, Amir; Aghababaie, Zahra; Afjoul, Homa; Abdi, Shabnam; Moravvej, Hamideh; Vossoughi, Manouchehr

doi:10.1016/j.ijpharm.2019.04.068

Cited by 70 publications

(32 citation statements)

References 22 publications

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“…Although at similar concentration SSD and AgNPs demonstrated strong and equal anti-microbial activity against S. aureus, AgNPs demonstrated higher biocompatibility, faster healing rate, epithelization, and dermal regeneration. The authors concluded that nano-silver was more efficient and more promising than silver sulfadiazine in wound healing application [118].…”

Section: Conclusion and Future Trendsmentioning

confidence: 99%

Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends

2019

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Recent data have reported that the burden of infections related to antibiotic-resistant bacteria in the European Union and European Economic Area (EEA) can be estimated as the cumulative burden of tuberculosis, influenza, and human immunodeficiency virus (HIV). In wound management, the control of infections represents a crucial issue and a multi-billion dollar industry worldwide. For diabetic wounds ulcers, in particular, infections are related to the majority of amputations in diabetic patients, which today represent an increasing number of the elderly. The greatest barrier to healing is represented by the biofilm, an organized consortium of bacteria encapsulated in a self-produced extracellular polymeric substance with high resistance to conventional antimicrobial therapies. There is an urgent need for novel anti-biofilm strategies and novel antimicrobial agents and, in this scenario, silver nanotechnology has received tremendous attention in recent years in therapeutically enhanced healthcare. Due to its intrinsic therapeutic properties and the broad-spectrum antimicrobial efficacy, silver nanoparticles have opened new horizons towards novel approaches in the control of infections in wound healing. This review aims at providing the reader with an overview of the most recent progress in silver nanotechnology, with a special focus on the role of silver in the wound healing process.

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Section: Conclusion and Future Trendsmentioning

confidence: 99%

Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends

2019

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“…SSD is a reliable anti-bacterial agent, and thus has recently been used as a coating material for indwelling catheters [ 48 , 49 ]. However, the mechanisms of action of SSD on BFs are still unclear.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Silver Sulfadiazine on Methicillin-Resistant Staphylococcus aureus Biofilms

et al. 2020

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Methicillin-resistant Staphylococcus aureus (MRSA), the most commonly detected drug-resistant microbe in hospitals, adheres to substrates and forms biofilms that are resistant to immunological responses and antimicrobial drugs. Currently, there is a need to develop alternative approaches for treating infections caused by biofilms to prevent delays in wound healing. Silver has long been used as a disinfectant, which is non-specific and has relatively low cytotoxicity. Silver sulfadiazine (SSD) is a chemical complex clinically used for the prevention of wound infections after injury. However, its effects on biofilms are still unclear. In this study, we aimed to analyze the mechanisms underlying SSD action on biofilms formed by MRSA. The antibacterial effects of SSD were a result of silver ions and not sulfadiazine. Ionized silver from SSD in culture media was lower than that from silver nitrate; however, SSD, rather than silver nitrate, eradicated mature biofilms by bacterial killing. In SSD, sulfadiazine selectively bound to biofilms, and silver ions were then liberated. Consequently, the addition of an ion-chelator reduced the bactericidal effects of SSD on biofilms. These results indicate that SSD is an effective compound for the eradication of biofilms; thus, SSD should be used for the removal of biofilms formed on wounds.

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“…37 There are some recent reports regarding the fabrication and evaluation of co-electrospun PCL and PLA membranes for wound healing applications. 38,39 Here, co-spinning was applied for the fabrication of wound dressing membranes composed of PCL bers and PVA bers encapsulated with SDF1.…”

Section: Introductionmentioning

confidence: 99%

Stromal cell-derived factor loaded co-electrospun hydrophilic/hydrophobic bicomponent membranes for wound protection and healing

et al. 2021

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A comparative study of wound dressings loaded with silver sulfadiazine and silver nanoparticles: In vitro and in vivo evaluation

Cited by 70 publications

References 22 publications

Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends

Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends

The Effects of Silver Sulfadiazine on Methicillin-Resistant Staphylococcus aureus Biofilms

Stromal cell-derived factor loaded co-electrospun hydrophilic/hydrophobic bicomponent membranes for wound protection and healing

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