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SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S)U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012
SPONSOR/MONITOR'S REPORT NUMBER(S)
DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited
SUPPLEMENTARY NOTES
ABSTRACTModern radiotherapy equipment is capable of delivering high precision conformal dose distributions to the target. However, the target localization especially for soft-tissue target such as prostate is an issue, because of its possible non-rigid internal motion relative to bony structures or external landmarks. Recently, a new technology of kV cone-beam CT (CBCT) has been integrated onboard with the linear accelerator. The prostate target localization could be potentially done more accurately with the aid of the on-board CBCT imager. In this project the PI group developed a novel technique of automatic patient positioning for prostate cancer radiation therapy. A few important milestones have been achieved toward the goal of the project. These include: (i) Established a novel technique to enhance on-board cone-beam CT and to effectively reduce the radiation dose incurred in the scanning process; (ii) Developed a robust registration model with improved metric function; (iii) Developed an innovative narrow shell technique for better target localization and model the critical structure; (iv) Established the method for auto-propagation of contours from planning CT to CBCT based on feature based spline deformable registration. With more evaluations, the automatic patient positioning technique and relevant research outcomes will soon be part of routine practice at Stanford University Hospital. The data and experiences we accumulated in this project are well documented, and server as a good reference for effectively utilizing CBCT imager, and will definitely enhance the outlook of the onboard CBCT in guiding radiation therapy as a whole.
SUBJECT TERMS