A comparative study of the effects of endurance and resistance exercise training on PON1 and lipid profile levels in obese men

Mahdirejei, Taleb Amouzad; Razi, Motaleb; Barari, Alireza; Farzanegi, Parvin; Mahdirejei, Hassan Amouzad; Shahrestani, Zabiholla; Ahmadi, Mojtaba

doi:10.1007/s11332-015-0232-2

Cited by 9 publications

(32 citation statements)

References 32 publications

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“…The findings of the current study showed that serum PON1 activity increased following endurance and sprint training at high intensity. The results are consistent with previous reports recording an increased serum PON1 activity after 4 to 10 weeks of aerobic exercise training (2,3,5). In contrast, the findings are inconsistent with other studies because of their low to moderate intensity of aerobic (9, 10) and resistance (2) exercise trainings.…”

Section: Discussionsupporting

confidence: 93%

“…The findings of the current study in healthy animals revealed that neither sprint nor endurance training effect serum lipid profile. Intriguingly, other studies have reported no significant change in serum LDL, HDL, and TG levels following exercise trainings at moderate intensity (2,3,5). Lipid profile factors are hardly affected by exercise training unless it is accompanied by nutritional modifications (2,3,25).…”

Section: Discussionmentioning

confidence: 88%

“…This 43-kDa glycoprotein enzyme with 345 amino acids is synthesized in the liver (2) and released in the blood (4). PON1 prevents oxidative modification of LDL and HDL (2,5), which in turn impedes the development of atherosclerosis (4). Although PON1 activity and concentration are determined genetically, several factors such as diet, lifestyle, and environmental factors can influence PON1 activity (7).…”

Section: Discussionmentioning

confidence: 99%

“…If HDL is not supported by PON1, it cannot perform its function very well (2,24). High-Density Lipoprotein acts as an anti-inflammatory agent in healthy individuals, yet is characterized by systemic oxidative stress and inflammation in chronic illnesses (3).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, an increased PON1 activity and HDL levels has been revealed following short-term exercise training in football players (7). Furthermore, intense aerobic exercise training corresponds to 60% to 85% maximum heart rate (2,3,5), resulting in increased PON1 activity, while no significant changes occur in LDL, HDL, and TG levels. In contrast, other researchers have reported that vigorous and moderate aerobic exercise trainings have no significant effects on PON1 activity and lipid profile levels (9)(10)(11).…”

Section: Introductionmentioning

confidence: 97%

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The Effect of Exercise Training Type on Paraoxonase-1 and Lipid Profile in Rats

et al. 2017

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Background: Paraoxonase-1 (PON1) is an anti-atherosclerotic enzyme that protects high-density lipoprotein (HDL) and low-density lipoprotein (LDL) against oxidation. There are contradictory studies about the effects of exercise training on PON1 activity. Objectives: The purpose of the present study was to elucidate the effects of sprint and endurance exercise training on serum PON1 activity and lipid profile in rats. Methods: Twenty-four Albino Wistar rats were divided to sedentary control (SC), endurance training (ET), and sprint training (ST) groups. The animals were subjected to endurance (at a speed of 27 m/minute) and sprint (at a speed of 40 to 54 m/minute) training on a treadmill for 6 weeks, 6 days per week. Using commercial kits, PON1 activity and lipid profile levels were measured by spectrophotometry and enzymatic methods, respectively. The data were analyzed by one-way analysis of variance followed by Tukey's post-hoc test at P < 0.05 level. Results: Both ET and ST regimens increased PON1 activity in the serum, and the alteration was greater following ST than ET (F1, 23 = 17.87, P = 0.001). In contrast, neither ST nor ET changed significantly the serum levels of triglyceride (F1, 23 = 0.288, P = 0.753), total cholesterol (F1, 23 = 0.385, P = 0.685), LDL (F1, 23 = 1.07, P = 0.361), and HDL (F1, 23 = 1.36, P = 0.277). In addition, serum PON1 activity was positively correlated with serum HDL levels in rats (R = 0.44, P = 0.032). Conclusions: Despite the lack of change in serum lipid profile, sprint training can lead to greater protection against lipid peroxidation than endurance training through increases in serum PON1 activity.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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The Effect of Exercise Training Type on Paraoxonase-1 and Lipid Profile in Rats

et al. 2017

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Do PON1–Q192R and PON1–L55M polymorphisms modify the effects of hypoxic training on paraoxonase and arylesterase activity?

Yigittürk

Turgay

Kızıldağ

et al. 2023

Journal of Sport and Health Science

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The effect of endurance and endurance-strength training on body composition and cardiometabolic markers in abdominally obese women: a randomised trial

Jamka

Mądry

Krzyżanowska-Jankowska

et al. 2021

Sci Rep

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Studies comparing the effect of endurance and endurance-strength training on cardiometabolic markers provided inconsistent results. Therefore, the study aimed to compare the effect of endurance and endurance-strength training on body composition and cardiometabolic parameters in abdominally obese women. In this randomised trial, 101 subjects were included and divided into endurance (n = 52) and endurance-strength (n = 49) training. During the 12-week intervention, participants performed supervised one-hour training three times a week. Body composition, blood pressure (BP), markers of glucose and lipid homeostasis, and myoglobin levels were measured before and after the intervention. In total, 85 subjects completed the trial. Both interventions decreased fat mass and visceral adipose tissue and increased free fat mass, appendicular lean mass index and lean mass index. Neither endurance training nor endurance-strength training affected glucose and lipid metabolism. However, only endurance training significantly decreased paraoxonase and myoglobin levels. Both training programmes significantly decreased BP, with a more reduction of diastolic BP noted in the endurance group. In conclusion, both training programmes had a favourable effect on body composition but did not improve glucose and lipid homeostasis. Besides, endurance training decreased paraoxonase activity and myoglobin levels and was more effective in reducing BP.The study was registered with the German Clinical Trials Register (DRKS) within the number: DRKS00019832 (retrospective registration), date of registration: 26/02/2020.

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A comparative study of the effects of endurance and resistance exercise training on PON1 and lipid profile levels in obese men

Cited by 9 publications

References 32 publications

The Effect of Exercise Training Type on Paraoxonase-1 and Lipid Profile in Rats

The Effect of Exercise Training Type on Paraoxonase-1 and Lipid Profile in Rats

Do PON1–Q192R and PON1–L55M polymorphisms modify the effects of hypoxic training on paraoxonase and arylesterase activity?

The effect of endurance and endurance-strength training on body composition and cardiometabolic markers in abdominally obese women: a randomised trial

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