A Comparative Study of the Effects of Citric Acid, Capsaicin and Resiniferatoxin on the Cough Challenge in Guinea-pig and Man

Laude, E; Higgins, KS; Morice, AH

doi:10.1006/pulp.1993.1023

Cited by 96 publications

(85 citation statements)

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“…Thus, inhaled capsaicin, predominantly a C-fibre ending stimulant, causes cough in man and in guinea-pig [9][10][11]. Inhalation of a citric acid aqueous solution is known to cause cough in guinea-pig and man, and this response seems to involve sensory mechanisms, since it is inhibited in the guinea-pig by pretreatment with high concentrations of capsaicin which causes degeneration of sensory nerves [2,3].…”

Section: Discussionmentioning

confidence: 99%

Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig

Girard¹,

Naline²,

Vilain³

et al. 1995

Eur Respir J

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E Ef ff fe ec ct t o of f t th he e t tw wo o t ta ac ch hy yk ki in ni in n a an nt ta ag go on ni is st ts s, , S SRIn conclusion, our results demonstrate that NK 2 -receptor stimulation plays a predominant role in the regulation of cough reflex, at least in the guinea-pig, as shown by the high potency and efficacy of SR 48968, a tachykinin NK 2 -receptor antagonist. SR 140333, a NK 1 -receptor antagonist is unable to inhibit cough by itself, but it potentiates SR 48968 in terms of efficiency. Finally, as salbutamol did not modify the effect of SR 48968, it may be suggested that the antitussive effect of SR 48968 is not related to the inhibition of citric acid-induced bronchoconstriction.

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Section: Discussionmentioning

confidence: 99%

Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig

Girard¹,

Naline²,

Vilain³

et al. 1995

Eur Respir J

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“…The majority of articles so far have focused on the role of capsaicin, and thereby the TRPV1 receptor, in the activation of the cough reflex [25][26][27]. Interestingly, the tussive activity of capsaicin was noted many years before the identification of TRPV1 [28,29].…”

Section: Trpv1mentioning

confidence: 99%

The emerging role of transient receptor potential channels in chronic lung disease

Belvisi

Birrell

2017

Eur Respir J

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Chronic lung diseases such as asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis are a major and increasing global health burden with a high unmet need. Drug discovery efforts in this area have been largely disappointing and so new therapeutic targets are needed. Transient receptor potential ion channels are emerging as possible therapeutic targets, given their widespread expression in the lung, their role in the modulation of inflammatory and structural changes and in the production of respiratory symptoms, such as bronchospasm and cough, seen in chronic lung disease.

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“…Tussive agents, such as capsaicin and low-pH solutions, are known vagal sensory nerve stimulants and, as such, isolated guinea pig and human vagus nerve preparations have been shown to elicit nerve depolarisation responses to these stimulants [14,17]. Furthermore, these agents are also known tussigenic agents in human and animal studies [16,18]. These data suggest that the isolated vagus nerve is an ideal preparation for conducting comprehensive pharmacological assessments of agents that may activate or inhibit sensory nerve function and thus the cough reflex.…”

Section: Measurement Of Sensory Nerve Depolarisation Of Isolated Vagumentioning

confidence: 99%

2-Agonists block tussive responses in guinea pigs via an atypical cAMP-dependent pathway

Freund-Michel

Birrell²,

Giembycz³

et al. 2009

European Respiratory Journal

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b 2 -Adrenoceptor agonists are the most effective bronchodilators currently available, and are used for symptom management in asthmatics. However, whether b 2 -agonists are also antitussive is controversial. Identifying an antitussive role for b 2 -agonists and dissecting the possible mechanism of action may help to explain the inconsistencies in the clinical literature and lead to the development of novel therapeutic agents. The aim of the present study was to determine whether or not b 2 -agonists attenuate the tussive response in guinea pig and human models, and, if so, to identify the mechanism(s) involved.Depolarisation of vagal sensory nerves (human and guinea pig) was assessed as an indicator of sensory nerve activity. Cough was measured in a conscious guinea pig model.A b 2 -agonist, terbutaline, dose-dependently inhibited the cough response to tussive agents in conscious guinea pigs. Terbutaline and another b 2 -agonist, fenoterol, blocked sensory nerve activation in vitro. Using these mechanistic models, it was established that b 2 -agonists suppress the tussive response via a nonclassical cyclic adenosine monosphosphate-dependent pathway that involves the activation of protein kinase G and, subsequently, the opening of largeconductance calcium-activated potassium channels.In conclusion, b 2 -adrenoceptor agonists are antitussive, and this property occurs due to a direct inhibition of sensory nerve activation. These findings may help to explain the confusion that exists in the clinical literature, and could be exploited to identify novel therapies for the treatment of cough, which is a significant unmet medical need.

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A Comparative Study of the Effects of Citric Acid, Capsaicin and Resiniferatoxin on the Cough Challenge in Guinea-pig and Man

Cited by 96 publications

References 0 publications

Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig

Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig

The emerging role of transient receptor potential channels in chronic lung disease

2-Agonists block tussive responses in guinea pigs via an atypical cAMP-dependent pathway

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