A Comparative Study of Single‐dose Growth Hormone Therapy as an Adjuvant to Gonadotrophin Treatment for Ovulation Induction

Homburg, Roy; West, Christopher C.; Torresani, T.; Jacobs, Howard S.

doi:10.1111/j.1365-2265.1990.tb00925.x

Cited by 40 publications

(20 citation statements)

References 10 publications

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“…In fact, several studies have demonstrated that GH treatment increases ovary sensitivity to gonadotropin stimulation in infertile women with hyposensitive ovaries (12)(13)(14)(15)(16)(17)(18)(19). The effect of GH administration on gonadal function in men has been poorly investigated.…”

Section: Introductionmentioning

confidence: 99%

The effect of chronic treatment with GH on gonadal function in men with isolated GH deficiency

Carani

Granata²,

Rosa³

et al. 1999

European Journal of Endocrinology

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Eleven adult males, previously submitted to neurosurgery because of a pituitary lesion (three with craniopharyngioma, three with clinically non-functioning adenoma and five with macroprolactinoma) were treated with recombinant GH for 12 months after the diagnosis of GH deficiency was made. Circulating FSH, LH, prolactin, testosterone, 17b-estradiol (E 2 ), dehyroepiandrosterone (DHEA-S), androstenedione, 17-OH-progesterone (17OHP), IGF-I, and steroid hormone-binding protein (SHBG) levels were assayed before and after CG test at study entry and 6 and 12 months after GH treatment.A significant increase in plasma IGF-I levels was obtained after 6 and 12 months of GH treatment. In addition, CG-stimulated, but not baseline, testosterone levels showed a significant increase after 6 and 12 months of GH treatment when compared with study entry (9.6Ϯ0.5 and 9.9Ϯ0.5 vs 7.9Ϯ0.5 ng/ ml; P<0.05). Baseline, but not CG-stimulated, serum 17OHP levels were significantly increased only after 12 months of GH treatment (1.7Ϯ0.1 vs 1.4Ϯ0.1 ng/ml; P<0.05). No significant difference was found as far as both basal and CG-stimulated E 2 , androstenedione, DHEA-S and SHBG were concerned. With regards to the semen analysis, only seminal plasma volume was significantly increased after 12 months of GH treatment (2.9Ϯ0.3 vs 1.7Ϯ0.3 ml; P<0.05). No significant change in sperm count, motility and abnormal forms was observed.These data show that GH treatment displays a clear-cut effect upon Leydig cell function and increases the production of seminal plasma volume in fertile adult males with isolated GH deficiency.

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Section: Introductionmentioning

confidence: 99%

The effect of chronic treatment with GH on gonadal function in men with isolated GH deficiency

Carani

Granata²,

Rosa³

et al. 1999

European Journal of Endocrinology

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“…At 21 days of age, MSG-treated rats received either GH or vehicle for 2 weeks. On days 21,24,28 and 31 animals were weighed and subsets were sacrificed for liver RNA extraction. The remaining animals were sacrificed at day 35 when livers and ovaries were collected, and serum was obtained for GH determinations.…”

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confidence: 99%

Growth hormone (GH) modulates insulin-like growth factor I (IGF-I) and type I IGF receptor mRNA levels in the ovary of prepubertal GH-deficient rats

Malozowski

Parmer

Trojan

et al. 1995

European Journal of Endocrinology

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In order to explore the potential role of growth hormone (GH) in modulating insulin-like growth factor I (IGF-I) gene expression in the prepubertal rat ovary, female rats were rendered GH deficient by neonatal administration of monosodium glutamate (MSG). One group of rats received vehicle and served as the control. At 21 days of age, MSG-treated rats received either GH or vehicle for 2 weeks. On days 21, 24, 28 and 31 animals were weighed and subsets were sacrificed for liver RNA extraction. The remaining animals were sacrificed at day 35 when livers and ovaries were collected, and serum was obtained for GH determinations. The IGF-I mRNA levels were estimated by Northern blots and corroborated further by slot-blot analysis. The MSG-treated rats had lower body weights (p < 0.01) and GH levels (p < 0.05) than controls. Growth hormone replacement significantly accelerated the weight gain of MSG-treated rats. At day 24 and thereafter, three RNA IGF-I species (7.5, 1.8 and 0.8-1.2 kB) were seen in the liver. In the ovary, at age 35 days, two major IGF-I mRNA species (7.5 and 0.8-1.2 kb) were seen. The MSG treatment consistently reduced the levels of both IGF-I mRNA species in the ovary. Growth hormone administration partially restored their expression, both in the liver and in the ovary. In addition, ovarian type IIGF receptor mRNA levels were increased in the MSG-treated rats when compared to controls. This trend was reversed by GH replacement.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…These changes were unaccompanied by changes in serum creatinine, sodium, potassium, bicarbonate, calcium or phosphate concen trations. [5] The purpose of this study was to compare the effect of a single dose of growth hormone added to hMG treat ment with that of the 6-dose protocol and with that of hMG alone.…”

Section: Resultsmentioning

confidence: 99%

Role of Growth Hormone in Infertility

Jacobs

Bouchard²,

Conway³

et al. 1991

Horm Res

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A Comparative Study of Single‐dose Growth Hormone Therapy as an Adjuvant to Gonadotrophin Treatment for Ovulation Induction

Cited by 40 publications

References 10 publications

The effect of chronic treatment with GH on gonadal function in men with isolated GH deficiency

The effect of chronic treatment with GH on gonadal function in men with isolated GH deficiency

Growth hormone (GH) modulates insulin-like growth factor I (IGF-I) and type I IGF receptor mRNA levels in the ovary of prepubertal GH-deficient rats

Role of Growth Hormone in Infertility

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