2006
DOI: 10.1016/j.pain.2006.02.006
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Abstract: Visceral pain can be difficult to treat with classical mu-opioid agonists and it has been suggested to use opioids with distinct pharmacological profiles. In animal experiments, oxycodone has shown different effects compared to morphine, and clinical observations have shown that oxycodone may occasionally be superior to, e.g., morphine in the treatment of visceral pain. In the current study, we randomised 24 healthy subjects to treatment with either morphine (30 mg), oxycodone (15 mg) or placebo in a crossover… Show more

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Cited by 149 publications
(185 citation statements)
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“…This dose is at upper end of the therapeutic range [37]. In the study by Staahl et al analgesia was seen for several pain parameters in various tissues and this group also applied a high dose, compared with the normal dose used in the clinic, although in the therapeutic range [5].…”
Section: Figurementioning
confidence: 99%
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“…This dose is at upper end of the therapeutic range [37]. In the study by Staahl et al analgesia was seen for several pain parameters in various tissues and this group also applied a high dose, compared with the normal dose used in the clinic, although in the therapeutic range [5].…”
Section: Figurementioning
confidence: 99%
“…Muscle: Morphine has been tested against pain from deep pressure algometry, electrical stimulation, cold pressor test, injection of hypertonic saline and ischaemic pain [5,53,[87][88][89][90]. Ischaemic pain, cold pressor pain and pain to electrical stimulations were decreased by morphine [87,[89][90][91][92].…”
Section: Figurementioning
confidence: 99%
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“…Sustained-release oral oxycodone is a strong analgesic that is simple and cheap to administer and that shows potential for treating pain in experimental human visceral pain models [20]. Early absorption of an oral dose of 20 mg of sustained-release oxycodone is rapid, with significant increases in blood concentration seen by 40 min, building to peak blood levels by 3.2 h [21], closely matching the profile of PI with UAE [4].…”
Section: Introductionmentioning
confidence: 99%