Background :High-risk behaviors is one of the most serious factors threatening the physical and mental health of adolescents and young adults. The aims of this study were to investigate thesubgroups of students based on risky behaviors and to identify the prevalence rate of these subgroups. Methods: This cross-sectional web-based survey was conducted from July to August 2019 in Tabriz, Iran. Sampling of all universities in the city was performed proportionally according to the number of students in each university. . Applying an online survey questionnaire, the data were collected from 3649 students and included into Latent Class Analysis. Results: For both genders, standardized prevalence rates of cigarrette smoking, hookah use, alcohol consumption, substance abuse and unsafe sex were 18.5 (CI 95%: 17.3-19.8), 9.1 (CI 95%: 8.2-10.1), 9.2 (CI 95%: 8.3-10.2), 8.3 (CI 95%: 7.4-9.3) and 14.5 (CI 95%: 13.3-15.7), respectively. Three latent classes of risky behaviors were determined among students: 1) low risk 2) smoking and 3) high risk. About 18% of boys and 1.5% of girls were in the high risk class. Cigarrette smoking (18.5%, CI 95%: 17.3-19.8) and substance abuse (8.3%, CI 95%: 7.4-9.3) were the most and the least common risky behaviors among the students. Conclusion: In this we-based survey, a considerable percentage of students, particularly boys, were at high-risk class, stressing the need for preventive interventions for this group of youth. Our findings are beneficial for planning and development of risky-behavior preventive measures to prevent high-risk behaviors among college students.