A Comparative Study of Attenuation of Stress Response During Intubation With Esmolol and Propofol

Abstract

BACKGROUND Endotracheal intubation for giving anaesthesia and for other purposes have become integral part of anaesthesiology. Tracheal intubation provides a patent airway for unconscious person. For endotracheal intubation, direct laryngoscopy is a tool. Direct laryngoscopy and passage of endotracheal tube are noxious stimuli that can provoke adverse responses in cardiovascular system. To prevent adverse responses different drugs are used in different methods. In the present study, we are comparing the effects of esmolol and propofol to obtund adverse responses in the cardiovascular system. MATERIALS AND METHODS Hospital-based prospective randomised comparative study, which includes 70 normotensive patients aged 15 to 60 years of either sex belonging to ASA I and II, Mallampati class 1 and 2 posted for various elective non-cardiac surgeries. In this study, the group 1 patients received esmolol 1 mg/kg bolus and in group 2 propofol 1 mg/kg bolus after 1 minute of induction. Haemodynamic parameters were recorded (SBP, DBP, MAP and HR) before and after intubation and compared. RESULTS The mean heart rate in both group 1 and 2 reduced significantly from preoperative value after 2 minutes of drug administration. The mean values of the haemodynamic parameters HR, SBP, DBP and MAP were compared in group 1 and 2 after 5 minutes of intubation. There is no statistically significance between the two groups as the p value >0.05. CONCLUSION Both esmolol and propofol were effective in attenuation of haemodynamic response to laryngoscopy and intubation.