A comparative study between Chinese propolis and Brazilian green propolis: metabolite profile and bioactivity

Yuan, Min; Yuan, Xiaohong; Pineda, Miguel; Liang, Zeyu; He, Jian; Sun, Shengwei; Pan, Tian-Ling; Li, Kunping

doi:10.1039/c9fo02051a

Cited by 31 publications

(31 citation statements)

References 38 publications

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“…These assays are mainly spectrophotometric, which include free radical scavenging (Pobiega et al., 2019), ferric reducing antioxidant power (Ahmed et al., 2017; Gülçin et al., 2010), and electrochemical methods (Rebiai et al, 2011). A lot of results have described the antimicrobial and antibacterial activity of propolis extracts, noting that phenolic compounds, terpenoids and nonaromatic acids are primarily responsible for the inhibiting microorganism growth (Bayram et al., 2017; Martinotti & Ranzato, 2015; Yuan et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

“…The chemical composition varies depending on the source of the plant. Propolis exhibits a broad spectrum of biological activities, including anticancer, antibacterial (Kasiotis et al., 2017) and antioxidant properties (Yuan et al., 2020). Many studies have indicated a particular interest in the antioxidant activities of propolis using various assays.…”

Section: Introductionmentioning

confidence: 99%

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Chinese Propolis: Ultrasound‐assisted enhanced ethanolic extraction, volatile components analysis, antioxidant and antibacterial activity comparison

Ding

Sheikh

et al. 2020

Food Science & Nutrition

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This study was aimed to enhance the extraction yield of propolis samples using ultrasound technology, analyze the volatile compounds, and compare the antioxidant and antimicrobial effect of propolis extracts of different areas. Four propolis samples were collected from different regions of China, namely: Linqing, Shandong Province (LSP); Yingchun, Heilongjiang Province (YHP); Changge, Henan Province (CHP); and Raohe, Heilongjiang Province (RHP). The ultrasound extracts of CHP and RHP showed a higher total phenolic content (TPC) of 201.78 ± 4.60 mgGAE/g and 166.071 ± 1.53 mgGAE/g, total flavonoid content (TFC) of 519.77 ± 29.90 and 341.227 ± 10.82 mg quercetin/g respectively, as well as high antioxidant and antibacterial activity. Conventional extraction showed 15%–20% lower yield for TPC ranging from 72.02 ± 1.99 to 155.95 ± 3.69 mg GAE/g, TFC ranges from 129.675 ± 6.82 to 412.83 ± 12.14 mg quercetin/g, with lower antibacterial activity. The antioxidant activity of propolis extracts was determined by assays of reducing power, DPPH*, FRAP*, TEAC*, hydroxyl radical scavenging activity and superoxide anion scavenging activity. Collectively, the antioxidant activities of extracts from CHP and RHP were higher than those of the other two extracts(YHP and LSP). All the extracts showed high antimicrobial activity on Staphylococcus aureus, Listeria monocytogenes, and Bacillus subtilis, but no effect on Escherichia coli. A total of 150 compounds in propolis were detected by GC/MS. Terpenes (RHP 34%, YHP 5%, LSP 18%, and CHP 12%) and alcohols (RHP 12%, YHP 13%, LSP 12%, and CHP 10%) showed the highest relative content among all other extracts.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chinese Propolis: Ultrasound‐assisted enhanced ethanolic extraction, volatile components analysis, antioxidant and antibacterial activity comparison

Ding

Sheikh

et al. 2020

Food Science & Nutrition

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“…In addition, the utilization of green propolis extract can provide relief to those who suffer from such disorders. Machado et al (2012), Wang et al (2018), Yuan et al (2020), andSoleimani et al (2021) demonstrated the action of green propolis extract and its isolated compounds such as baccharin ( 19), artepillin C (20) and kaempferide (21) on several fronts of anti-inflammatory action (e.g., reductions in the manifestation of inflammatory genes, production of nitric oxide, and blocking of the manifestation of proinflammatory cytokines). Moreover, the extract increased antiinflammatory factors such as mucosal protective agents like luminal mucin production and expression of anti-inflammatory cytokines (Machado et al, 2012;Soleimani et al, 2021;Wang et al, 2018;Yuan et al, 2020).…”

Section: Anti -Infl Ammatory Ac Tivit Y Of G Reen Prop Olismentioning

confidence: 99%

A review on the anti‐inflammatory activities of Brazilian green, brown and red propolis

Santos

Morais-Urano

Cunha

et al. 2022

Journal of Food Biochemistry

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Humanity has used propolis since ancient times, and its use as a food supplement has significantly increased. Several reports on propolis´ biological activity and toxicity have highlighted its anti‐inflammatory properties, unlike many natural food supplements. This review addresses the anti‐inflammatory roles of Brazilian green, brown, and red propolis produced by Apis mellifera, their extracts, isolated compounds, and their mode of action. Despite advances in anti‐inflammatory therapies, the development of inflammatory processes in several diseases has been a concern for centuries. Demands for new anti‐inflammatory drugs have led to studies on propolis products as diet components to treat and prevent inflammatory disorders. Brazilian green, brown, and red propolis are alternatives for obtaining extracts and compounds of valuable anti‐inflammatory properties. Practical applications Currently, propolis is a food supplement, and to the best of our knowledge, several studies have shown that despite advances in anti‐inflammatory therapies, the inflammatory process continues to be a significant concern. However, due to the demand for new anti‐inflammatory drugs, propolis products as dietary components can be used to treat and prevent inflammatory disorders.

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“…DSS (dextran sodium sulfate) was found to produce typical UC lesions in mice. 24 RAW 264.7 macrophage cells are commonly used to examine the effects of anti-inflammatory compounds. 10,13 Therefore, this study aimed to analyze functional compounds in AE extract by HPLC, and to investigate the protective effects of AE extracts in mice that received DSS, and RAW 264.7 cells exposed to LPS.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effects ofAralia elataExtract Against Dextran Sodium Sulfate-Induced Colitis in Mice and Raw 264.7 Macrophage Cells Exposed to Lipopolysaccharide: First Report

Lee

Adam

et al. 2022

Natural Product Communications

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Aralia elata (AE) is an anti-inflammatory, polyphenolic containing medicinal plant. However, little is known about AE and its application to ulcerative colitis (UC). This study aimed to confirm AE extract's antioxidant and anti-inflammatory effects in vivo and in vitro. The in vitro antioxidant activity was evaluated by measuring total polyphenol and flavonoid content in AE extract. AE extract (10 000 mg/L) contained 186.8 mg GAE/g polyphenol and 81.9 mg QE/g flavonoid. Mice were divided into 6 groups, including control, which received normal saline, and treatment groups, which received dextran sodium sulfate (DSS) with or without AE extract (250, 500, and 1000 mg/kg). RAW 264.7 macrophage cells were divided into 2 groups: control and treatment. RAW 264.7 macrophage cells treated with sterile double distilled water, 1 mg/L lipopolysaccharide (LPS), and AE extracts (25, 50, 75, 100 µg/mL) were used to assess the cytotoxicity and anti-inflammatory activity. High-performance liquid chromatography, enzyme-linked immunosorbent assay (ELISA) kits, and histology were employed to analyze the AE extract contents, nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6, as oxidative stress markers. In addition, the disease activity index (DAI) and cytotoxicity were determined in mice and cells, respectively. High-performance liquid chromatography analysis revealed that AE extract is rich in chlorogenic acid (96 ± 0.01 mg/g). DSS increased the DAI and levels of TNF-α, IL-1β, and immune cell infiltration compared with those of the control animals. Furthermore, LPS eventually reduced cell viability and increased the levels of NO, TNF-α, IL-1β, and IL-6 in contrast to control cells. After treatment, a noticeable reduction was observed in the levels of DAI, NO, TNF-α, IL-1β, and IL-6 compared to those without AE treatments. Overall, AE extract is safe and had anti-inflammatory properties. Therefore, AE extract can be considered a potential pre-treatment supplement for UC.

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A comparative study between Chinese propolis and Brazilian green propolis: metabolite profile and bioactivity

Abstract: A comparative study between Chinese propolis and Brazilian green propolis showed that they have a distinct chemome but similar antioxidant and anti-inflammatory potential.

Cited by 31 publications

References 38 publications

Chinese Propolis: Ultrasound‐assisted enhanced ethanolic extraction, volatile components analysis, antioxidant and antibacterial activity comparison

Chinese Propolis: Ultrasound‐assisted enhanced ethanolic extraction, volatile components analysis, antioxidant and antibacterial activity comparison

A review on the anti‐inflammatory activities of Brazilian green, brown and red propolis

Anti-Inflammatory Effects ofAralia elataExtract Against Dextran Sodium Sulfate-Induced Colitis in Mice and Raw 264.7 Macrophage Cells Exposed to Lipopolysaccharide: First Report

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