A Comparative Biomechanical Evaluation of Hernia Mesh Fixation by Fibrin Sealant

Use of fibrin sealant (Tisseel/Tissucol) in hernia repair: a systematic review

“…In addition to these clinical findings, experimental studies by Erikson et al [15], Clark et al [61], Rieder et al [62], and Fortelny et al [16] verified that fibrin sealant could significantly reduce the numbers of perforating fixation devices for mesh fixation. Thus, a reduction of tissue trauma and nerve injuries could be achieved.…”

“…Tissucol is indicated in a variety of procedures (refer to country-specific prescribing information) to improve hemostasis, to seal or glue tissue, and to support wound healing [8]. The rationale for the use of Tisseel/ Tissucol in hernia repair was established through in vitro biomechanical and animal studies, beyond the scope of this review, which demonstrated strong mechanical strength and repair [6,[9][10][11][12][13][14][15][16], prevention of adhesion formation [17][18][19], and improved [6,18] or similar [13][14][15] tissue integration compared to traditional mesh fixation methods. The purpose of our review is to elucidate the efficacy and safety of Tisseel/Tissucol, a widely used adhesive in the field.…”

The impact of hydrophobic hernia mesh coating by omega fatty acid on atraumatic fibrin sealant fixation

“…This thrombin concentration was chosen because the slower polymerisation process compared to standard 500 IU allows repositioning of the mesh (8).…”

“…However, non-fixation is not recommended for the repair of large direct hernias and many TAPP surgeons still use FS routinely [8,14,28,30]. Among others three-dimensional fixation of the implant and coverage by a thin layer of sealant when applied with a spray device is a key advantage of this technique [10,25].…”

The impact of atraumatic fibrin sealant vs. staple mesh fixation in TAPP hernia repair on chronic pain and quality of life: results of a randomized controlled study

“…fibrin sealant (FS), seems to be a good alternative. In several studies on hernioplasty via open and endoscopic repair, atraumatic mesh fixation with FS proved to be efficient in terms of fixation strength, elasticity, and quality of life (QoL) [4][5][6][7][8][9][10][11][12][13][14][15]. The learning curve seems to play an important role in TAPP repair [16] and demands clarification if mesh fixation via ST in experienced hands leads to equally good results in terms of patient safety and satisfaction.…”