A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: effects on growth and development

Lind, Torbjörn; Lönnerdal, Bo; Stenlund, Hans; Gamayanti, Indria Laksmi; Ismail, Djauhar; Seswandhana, Rosadi; Persson, Lars‐Åke

doi:10.1093/ajcn/80.3.729

Cited by 178 publications

(179 citation statements)

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“…The interesting result in this study was the loss of the positive effect of zinc supplementation on weight gain when iron was added in the supplement, an effect that was also found in one study in Indonesian infants (Lind et al, 2004). And, despite the fact that weight gain in the placebo group was not significantly different from the iron group, the factorial analysis indicated that iron supplementation was associated with lower WAZ and weight-for-height indexes.…”

Section: Discussionsupporting

confidence: 70%

“…A recent study also conducted in Indonesian infants with a similar design shows no impact of zinc or iron or combined ironzinc supplementation on HAZ but improvement of kneeheel length with zinc or iron supplementation alone (Lind et al, 2004). This positive effect of zinc or iron supplements on knee-heel length is not shown in the former study carried out in the same country (Dijkhuizen et al, 2001).…”

Section: Discussionmentioning

confidence: 86%

“…The positive effect of zinc supplementation on weight gain has been already demonstrated in malnourished children (Golden and Golden, 1981), in Guatemalan (Rivera et al, 1998), Brazilian (Lira et al, 1998) and Indonesian infants (Lind et al, 2004) and in Zimbabwean schoolchildren (Friis et al, 1997) and was attributed to an increase synthesis of the lean body mass (Golden and Golden, 1981;Friis et al, 1997;Rivera et al, 1998). In contrast, another study concludes that zinc has no effect on height or weight gain but on body composition increasing the fat status of Guatemalan (Cavan et al, 1993).…”

Section: Discussionmentioning

confidence: 96%

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Efficacy of combined iron and zinc supplementation on micronutrient status and growth in Vietnamese infants

et al. 2005

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Objective: To evaluate the effect of combined iron-zinc supplementation on micronutrient status, growth and morbidity. Design: Randomized, double-masked, placebo-controlled supplementation trial. Setting: Rural district of Que Vo, in the Red River Delta in Vietnam. Subjects: A total of 915 breast-fed infants aged 4-7 months were included and 784 completed the study. Interventions: The Fe-group received daily and for a 6-month period 10 mg of iron, the Zn-group 10 mg zinc, the Fe-Zn group 10 mg iron þ 10 mg zinc and the placebo group a placebo. Hemoglobin (Hb), serum ferritin (SF) and zinc (SZn), and anthropometry were measured before and at the end of the intervention. Morbidity was recorded daily. Results: Changes of Hb and SF were higher in both Fe and Fe þ Zn groups (respectively 22.6 and 20.6 g/l for Hb; 36.0 and 24.8 mg/l for SF) compared to Zn and placebo groups (Hb: 6.4 and 9.8 g/l; SF: À18.2 and À16.9 mg/l, Po0.0001). SZn increased more in Zn group (10.3 mmol/l) than in Fe þ Zn group (8.0 mmol/l, P ¼ 0.03) and more in these groups compared to Fe and placebo groups (1.6 and 1.2 mmol/l, Po0.0001). Weight gain was higher in the Zn group. No significant effects of supplementations on growth in length or morbidity. Conclusions: Combined iron-zinc supplementation had a positive effect on iron and zinc status in infants. However, the positive effect of zinc alone on SZn and weight would indicate a negative interaction of iron when added to zinc supplements. Sponsorship: UNICEF New York.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 96%

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Efficacy of combined iron and zinc supplementation on micronutrient status and growth in Vietnamese infants

et al. 2005

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“…The foetus is totally dependent on the mother for the supply of nutrients essential to maintain its life. An optimal maternal nutritional status has been shown to reduce the risks of a preterm birth and low birth weight (1)(2)(3) , improve postnatal growth (4,5) , and reduce both maternal and infant morbidity and mortality (6)(7)(8)(9) . Despite a trend of improved infant growth in most countries due to enhanced intakes of macronutrients (10) , a low maternal nutritional status during the critical stage of foetal development subsequently contributes to growth retardation in the offspring and adverse health outcomes in later life (11) .…”

mentioning

confidence: 99%

Association of antioxidant vitamins and oxidative stress levels in pregnancy with infant growth during the first year of life

Hong

Park²,

Kim³

et al. 2008

Public Health Nutr.

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Objective: Whereas there are numerous reports in the literature relating the impact of maternal nutritional status on subsequent birth outcome, much less is known about the long-term impact on infant growth after birth. Therefore, we conducted a prospective cohort study to investigate the association of maternal micronutrient status (vitamins A, C and E, folate) and oxidative stress status in pregnancy with infant growth during the first year of life. Design: Prospective cohort study. Setting: Outpatient clinic of obstetrics, Ewha Womans University Hospital, Seoul, South Korea. Subjects and methods: Two groups were constructed for this study -the Ewha pregnancy cohort (n 5 677) and the infant growth cohort comprising follow-up live newborns of all the recruited pregnant women (n 5 317). Maternal serum vitamin and urinary oxidative stress levels were collected and infant weights and heights were measured at birth and at 6 and 12 months after birth. Results: Division of the subjects into folate-deficient and normal groups revealed that infant weight and height at 0, 6 and 12 months were adversely affected by folate deficiency. High maternal vitamin C was associated with increased infant weight and height at birth and after birth. Conclusion: Our findings indicate the importance of preventing folate deficiency and supplementing vitamin C during pregnancy.

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“…Los estudios realizados en niños sin desnutrición no han encontrado cambios significativos en el crecimiento. Otros estudios han demostrado el efecto del zinc sobre la talla y el peso al suministrarlo por 12 meses o más (25,35).…”

Section: Discussionunclassified

Efecto del zinc aminoquelado y el sulfato de zinc en la incidencia de la infección respiratoria y la diarrea en niños preescolares de centros infantiles

Sánchez¹,

Villada²,

Rojas³

et al. 2013

biomedica

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Biomédica 2014;34:79-91 El zinc en la incidencia de la infección respiratoria y la diarrea Contribución de los autores:Juliana Sánchez y Oscar Villada: análisis estadístico, interpretación de los resultados y redacción del manuscrito. Liliana Patricia Montoya, Ana Milena Herrera, Maylen Liseth Rojas, Alejandro Díaz, Javier Chica y Cristian Vargas: análisis de los resultados. Todos los autores participaron en el diseño y ejecución del estudio, la revisión y la aprobación de la versión final del manuscrito Introducción. El déficit de zinc es común en niños de poblaciones en desarrollo. La deficiencia de zinc altera el sistema inmunológico y la resistencia a las infecciones. Objetivo. Evaluar el efecto de dos compuestos de zinc en la prevención de la infección respiratoria y la diarrea agudas. Materiales y métodos. Se llevó a cabo un ensayo comunitario triple ciego en 301 niños entre dos y cinco años de edad de centros infantiles de Medellín. Fueron seis conglomerados distribuidos aleatoriamente en tres grupos de intervención que recibieron zinc aminoquelado, sulfato de zinc y placebo durante cinco días de la semana a lo largo de 16 semanas. Se evaluaron diariamente los síntomas de infección respiratoria, diarrea aguda y efectos secundarios.Resultados. La incidencia de la infección respiratoria fue menor con el zinc aminoquelado (1,42 por 1.000 días-niño) comparado con el sulfato de zinc (1,57 por 1.000 días-niño) (RR=0,90, IC 95% : 0,382 a 2,153, p=0,999) y con el placebo (3,3 por 1.000 días-niño) (RR=0,43, IC 95% : 0,196 a 0,950, p=0,049). La incidencia de diarrea aguda con el zinc aminoquelado (0,15 por 1.000 días-niño) fue menor que con el sulfato de zinc (1,18 0,78 por 1.000 días-niño) (RR=0,20, IC 95% : 0,0043 a 1,662, p=0,361) y que la del grupo placebo (0,49 por 1.000 días-niño) (RR=0,32, IC 95% : 0,006 a 3,990, p=0,346). Conclusiones. El zinc aminoquelado tuvo mejor efecto en la disminución de la incidencia de la infección respiratoria y la diarrea agudas en niños preescolares comparado con los otros grupos de estudio. Effect of zinc amino acid chelate and zinc sulfate in the incidence of respiratory infection and diarrhea among preschool children in child daycare centers Introduction: Zinc deficiency is common in children among populations in developing areas. Zinc deficiency alters the immune system and the resistance to infections. Objective: To evaluate the effect of two zinc compounds in the prevention of acute respiratory infection and acute diarrhea. Materials and methods: Randomized triple-blind community trial with 301 children between 2-5 years of age from six child daycare centers in Medellin, Colombia. Children were distributed in three groups receiving zinc amino acid chelate, zinc sulfate and placebo five days a week for 16 weeks. Daily symptoms of respiratory infection, acute diarrhea and side effects were evaluated. Results: The incidence of respiratory infection was lower with zinc amino acid chelate (1.42 per 1,000 child-days) compared with placebo (3.3 per 1,000 child-days) (RR=0.43, ...

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A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: effects on growth and development

Cited by 178 publications

References 41 publications

Efficacy of combined iron and zinc supplementation on micronutrient status and growth in Vietnamese infants

Efficacy of combined iron and zinc supplementation on micronutrient status and growth in Vietnamese infants

Association of antioxidant vitamins and oxidative stress levels in pregnancy with infant growth during the first year of life

Efecto del zinc aminoquelado y el sulfato de zinc en la incidencia de la infección respiratoria y la diarrea en niños preescolares de centros infantiles

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