A Combined Polymorphic Epidermal and Adnexal Tumor in Nevus Unius Lateris

Appendage tumors of the skin: histogenesis and ultrastructure

“…This tumor shows eecrine ductal differentiation, particularly that of acrosyringium; thus, the lumen is surrounded with 9D. 10. Fig.…”

“…Some eells from the same eell line produee dome-shaped strueture; the cross seetion of these domes reveals lumen formation (L) within the dome (X15). degrees of differrentiation are ptesent in the same lesion (9)(10)(11)(12). In sotne tutnors, the epidermis eovering the lesion produees hair or ecerine gland germs (Figs.…”

“…Nuclei (n) become less distinct and shadowy as cytoplasm becomes packed with these fibers, m: melanosomes g^ff!^^^F ig. 10. Pilomatricoma.…”

“…Thete are many reports of eombined adnexal tumors in whieh skin appendages of various degrees of differrentiation are ptesent in the same lesion (9)(10)(11)(12). For example, in nevus sebaeeous, epidermal hyperplasia, sebaceous gland adenoma, apoerine nevus and basal eell epithclioma may oecur one by one aeeording to the predetermined tnutational schedule.…”