A Cognitive Neuroscience View of Voice-Processing Abnormalities in Schizophrenia

Conde, Tatiana; Gonçalves, Óscar F.; Pinheiro, Ana P.

doi:10.1097/hrp.0000000000000082

Cited by 23 publications

(20 citation statements)

References 142 publications

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“…Further, we hypothesized that pre-stimulus alpha power would be reduced for self-generated stimuli as a function of increased HP, reflecting altered prediction formation. We specifically hypothesized that altered prediction and sensory feedback in high HP would be enhanced for voice stimuli 41 .…”

Section: The Current Study and Hypothesesmentioning

confidence: 99%

Voice-selective prediction alterations in nonclinical voice hearers

Pinheiro

Schwartze

Kotz

2018

Sci Rep

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102

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Auditory verbal hallucinations (AVH) are a cardinal symptom of psychosis but also occur in 6–13% of the general population. Voice perception is thought to engage an internal forward model that generates predictions, preparing the auditory cortex for upcoming sensory feedback. Impaired processing of sensory feedback in vocalization seems to underlie the experience of AVH in psychosis, but whether this is the case in nonclinical voice hearers remains unclear. The current study used electroencephalography (EEG) to investigate whether and how hallucination predisposition (HP) modulates the internal forward model in response to self-initiated tones and self-voices. Participants varying in HP (based on the Launay-Slade Hallucination Scale) listened to self-generated and externally generated tones or self-voices. HP did not affect responses to self vs. externally generated tones. However, HP altered the processing of the self-generated voice: increased HP was associated with increased pre-stimulus alpha power and increased N1 response to the self-generated voice. HP did not affect the P2 response to voices. These findings confirm that both prediction and comparison of predicted and perceived feedback to a self-generated voice are altered in individuals with AVH predisposition. Specific alterations in the processing of self-generated vocalizations may establish a core feature of the psychosis continuum.

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Section: The Current Study and Hypothesesmentioning

confidence: 99%

Voice-selective prediction alterations in nonclinical voice hearers

Pinheiro

Schwartze

Kotz

2018

Sci Rep

Self Cite

102

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“…This finding provides converging support for our suggestion that DMN hyperactivity may play a key role in the interaction between AVHs and poor insight. [ 1 2 3 4 5 ]…”

mentioning

confidence: 99%

Aberrant Functional Connectivity Patterns of Default Mode Network May Play a Key Role in the Interaction between Auditory Verbal Hallucinations and Insight

Jing

Shen

Zhang

et al. 2018

Chinese Medical Journal

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“…However, it is possible that the experience of AVH is associated with specific abnormalities in voice information processing pathways (i.e., identity, speech, affect; Belin, Fecteau, & B edard, 2004). For example, AVH have been more strongly and consistently associated with alterations in the processing of voice identity and semantic content of speech (see Conde, Gonçalves, & Pinheiro, 2016, for a review).…”

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confidence: 99%

Emotional self–other voice processing in schizophrenia and its relationship with hallucinations: ERP evidence

et al. 2017

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Abnormalities in self-other voice processing have been observed in schizophrenia, and may underlie the experience of hallucinations. More recent studies demonstrated that these impairments are enhanced for speech stimuli with negative content. Nonetheless, few studies probed the temporal dynamics of self versus nonself speech processing in schizophrenia and, particularly, the impact of semantic valence on self-other voice discrimination. In the current study, we examined these questions, and additionally probed whether impairments in these processes are associated with the experience of hallucinations. Fifteen schizophrenia patients and 16 healthy controls listened to 420 prerecorded adjectives differing in voice identity (self-generated [SGS] versus nonself speech [NSS]) and semantic valence (neutral, positive, and negative), while EEG data were recorded. The N1, P2, and late positive potential (LPP) ERP components were analyzed. ERP results revealed group differences in the interaction between voice identity and valence in the P2 and LPP components. Specifically, LPP amplitude was reduced in patients compared with healthy subjects for SGS and NSS with negative content. Further, auditory hallucinations severity was significantly predicted by LPP amplitude: the higher the SAPS "voices conversing" score, the larger the difference in LPP amplitude between negative and positive NSS. The absence of group differences in the N1 suggests that self-other voice processing abnormalities in schizophrenia are not primarily driven by disrupted sensory processing of voice acoustic information. The association between LPP amplitude and hallucination severity suggests that auditory hallucinations are associated with enhanced sustained attention to negative cues conveyed by a nonself voice.

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A Cognitive Neuroscience View of Voice-Processing Abnormalities in Schizophrenia

Cited by 23 publications

References 142 publications

Voice-selective prediction alterations in nonclinical voice hearers

Voice-selective prediction alterations in nonclinical voice hearers

Aberrant Functional Connectivity Patterns of Default Mode Network May Play a Key Role in the Interaction between Auditory Verbal Hallucinations and Insight

Emotional self–other voice processing in schizophrenia and its relationship with hallucinations: ERP evidence

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