A clinicopathological study of interface dermatitis

Hegde, Vijaya; Khadilkar, Urmila N

doi:10.4103/0377-4929.138723

Cited by 13 publications

(29 citation statements)

References 9 publications

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“…Biopsy from the lesions of Koebner's phenomena was taken in two cases which had changes of classical lichen planus along with band like lymphocytic infiltration. The classic degeneration of basement membrane was found most correlated parameter in our study as well as in the study by Ellis Francis (1967) followed by Hegde and Khadilkar (2014). In our study it was seen in 65 patients out of 117.…”

Section: Discussionsupporting

confidence: 88%

“…However in 16 cases the basement membrane squamatization was found at few sites only. Civatte bodies though are one of the key features in the four major histological changes in lichenoid dermatoses histopathologically they were found to be less correlated in ours as well in other similar studies (Hegde and Khadilkar, 2014). Caspary-Joseph spaces were seen in very few cases (2.5%) in our study.…”

Section: Discussioncontrasting

confidence: 76%

“…A study on lichen striatus behaving as a chameleon in dermatopathology was done by Gianotti et al (1995). Hypergranulosis was seen in 49.5% cases of our study (17% in another study (Hegde and Khadilkar, 2014) in which 65% of cases were having Wickham's striae clinically. Focal wedge shaped hypergranulosis was present in 100% cases of hypertrophic, plantar and linear lichen planus and 63% cases of classical lichen planus.…”

Section: Discussionmentioning

confidence: 42%

“…Acanthosis which is saw toothing of rete ridges was found in 55.5% of study. Acanthosis was observed in other studies but proportion was in between 15% and 83% proving to be an inconsistent feature for diagnosis (Desai et al, 2014;Hegde and Khadilkar, 2014). In majority of the cases of lichen striatus epidermal changes of parakeratosis, psoriasiform hyperplasia of rete ridges, with focal basement membrane degeneration and in dermis perivascular and perifollicular infiltration was seen which was consistent with its pathognomonic features.…”

Section: Discussionmentioning

confidence: 62%

“…The term ''lichenoid" refers to papular lesions of which lichen planus is a prototype (Hegde and Khadilkar, 2014). Lichen is derived from Greek noun ''lichen" meaning tree moss (Khopkar and Valia, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Clinico-histopathological correlation for diagnosis of lichenoid interface dermatoses

Maheshwari¹,

Mehta²,

Nikam³

2016

Journal of Dermatology & Dermatologic Surgery

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Context: Lichenoid interface dermatitis refers to the histological pattern which is useful for the classification and diagnosis of disorders of a particular group in dermatology with peculiar features.Aims: To get clinico pathological correlation in lichenoid interface dermatitis which will help in accurate diagnosis by analyzing history, clinical examination as well as histological details of nature and extent of epidermal, interface and dermal changes and the distribution of various inflammatory cell infiltrates.Methods: After appropriate case selection according to the inclusion criteria, the biopsy was taken and sent for histopathological analysis. It was reviewed and correlation was done in each patient.Statistical analysis used: kappa correlation analysis. Results: Out of total 117 cases, 108 were of lichen planus, five were of lichen striatus, two of lichenoid drug eruptions and two of lichen nitidus. Clinico-pathological correlation was present in 70.94% of cases of lichenoid interface dermatitis. Correlation was seen in 100% cases of lichen striatus, and 78% cases of lichen planus.Conclusions: The most consistent findings in histology in our study were basement membrane degeneration, band like lymphocytic infiltrates and melanin incontinence. Other findings such as hypergranulosis, civatte bodies were not observed frequently.

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Section: Discussionsupporting

confidence: 88%

Section: Discussioncontrasting

confidence: 76%

Section: Discussionmentioning

confidence: 42%

Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinico-histopathological correlation for diagnosis of lichenoid interface dermatoses

Maheshwari¹,

Mehta²,

Nikam³

2016

Journal of Dermatology & Dermatologic Surgery

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An overview of S100 proteins and their functions in skin homeostasis, interface dermatitis conditions and other skin pathologies

Abdi,

Romasco,

Alkurdi

et al. 2024

Experimental Dermatology

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S100 proteins comprise a family of structurally related proteins that are calcium‐sensitive. S100 proteins have been found to play various roles in regulation of cell apoptosis, cell proliferation and differentiation, cell migration and invasion, energy metabolism, calcium homeostasis, protein phosphorylation, anti‐microbial activity and inflammation in a variety of cell types. While the specific function of many S100 proteins remains unknown, some of the S100 proteins serve as disease biomarkers as well as possible therapeutic targets in skin diseases. Interface dermatitis (ID) is a histopathological term that covers many different skin conditions including cutaneous lupus erythematosus, lichen planus, and dermatomyositis. These pathologies share similar histological features, which include basal cell vacuolization and lymphocytic infiltration at the dermal‐epidermal junction. In this review, we summarize how the S100 protein family contributes to both homeostatic and inflammatory processes in the skin. We also highlight the role of S100 proteins in neuronal signalling, describing how this might contribute to neuroimmune interactions in ID and other skin pathologies. Last, we discuss what is known about the S100 family proteins as both biomarkers and potential treatment targets in specific pathologies.

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A clinico-pathological study of lichenoid tissue reactions/interface dermatitis

2019

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Background: Lichenoid tissue reaction/Interface dermatitis (LTR/ID) refers to a number of clinically diverse, poorly understood and relatively uncommon inflammatory skin diseases. This study was done to understand the histopathological features of lichenoid tissue reactions in skin biopsies and to assess the concordance and disparity between the clinical and histopathological diagnosis of variants of the same.Methods: It was a 3½ years study from January 2014 to June 2017 in the department of Pathology, KIMS, Hubballi. The present study included skin biopsies of clinically diagnosed and suspected cases and histologically diagnosed cases of LTRs. Skin biopsies received were routinely paraffin processed and H&E stained to study the microscopic features.Results: Out of 166 skin biopsies studied, 148 were histologically confirmed as LTR with majority being of lichen planus (LP) (91.22%). Classical lichen planus was the most common variant of lichen planus among lichen planus cases. Male:female ratio was 1.2:1. Clinico-pathological concordance was seen in 88.55% of the cases.Conclusions: Though definite diagnosis can be made on histopathological examination, size of specimen, site of biopsy, nature and depth of biopsy, quality of sections, treatment history and inter-observer variation (both clinically and histologically) should be kept in mind which may lead to clinicopathological discordance.

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A clinicopathological study of interface dermatitis

Abstract: The mere presence of an interface lichenoid inflammatory reaction should not be the sole criterion for the diagnosis of LP or one of its many variants, as now seems to be the case. A clinicopathologic correlation is absolutely essential for a conclusive diagnosis of ID.

Cited by 13 publications

References 9 publications

Clinico-histopathological correlation for diagnosis of lichenoid interface dermatoses

Clinico-histopathological correlation for diagnosis of lichenoid interface dermatoses

An overview of S100 proteins and their functions in skin homeostasis, interface dermatitis conditions and other skin pathologies

A clinico-pathological study of lichenoid tissue reactions/interface dermatitis

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