A Clinicopathologic Study of the Skin in Mongolism

Kersting, David W.

doi:10.1001/archderm.1958.01560030065010

Cited by 20 publications

(2 citation statements)

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“…In their series, only one patient had psoriasis. The above studies indicate that psoriasis is not a common complication of Down syndrome (1)(2)(3). However, extreme hyperkeratotic psoriasis has been reported (4,5).…”

Section: Discussionmentioning

confidence: 91%

Ichthyosis and Psoriasis in a Patient with Down Syndrome

Nomura

1999

The Journal of Dermatology

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Section: Discussionmentioning

confidence: 91%

Ichthyosis and Psoriasis in a Patient with Down Syndrome

Nomura

1999

The Journal of Dermatology

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“…This could be further confirmed in a study of Geetha et al, in which the proportion of non-responders to pilocarpine was significantly higher in DS patients (> 10%) then in the normal population (3%) [ 8 ]. The higher non-responder rate and the difficulty to obtain enough sweat could be due to an abnormal skin commonly found in children with DS [ 17 ]. In this context, the anatomy of sweat glands seems to be different in patients with DS.…”

Section: Discussionmentioning

confidence: 99%

Is sweat testing for cystic fibrosis feasible in patients with down syndrome?

et al. 2018

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BackgroundRecurrent airway infections are common in patients with Down’s syndrome (DS). Hence, ruling out Cystic Fibrosis (CF) in these patients is often required. In the past, the value of sweat testing – the gold standard to diagnose CF – has been questioned in DS as false positive results have been reported. However, these reports are based on measurements of sweat osmolality or sodium concentrations, not chloride concentrations. This study analyses sweat secretion rate and chloride concentration in sweat samples of patients with DS in comparison to healthy controls.MethodsWe assessed sweat samples in 16 patients with DS and 16 healthy controls regarding sweat secretion rate (SSR) and sweat chloride concentration.ResultsAll measured chloride concentrations were within the normal range. The chloride concentrations were slightly, but not significantly lower in patients with DS (15,54 mmol/l (±4,47)) compared to healthy controls (18,31 mmol/l (±10,12)). While no gender gap in chloride concentration could be found, chloride concentration increased with age in both groups.Insufficient sweat was collected in 2 females with DS (12.5% of the study group) but not in an individual of the control group. A significant lower sweat secretion rate was found in the DS group (27,6 μl/30 min (± 12,18)) compared to the control group (42,7 μl/30 min (± 21,22)). In a sub-analysis, female patients produced significantly less sweat (20,8 ± 10,6 μl/30 min) than male patients with DS (36,4 ± 7,8 μl/30 min), which accounts for the difference between patients and controls. Furthermore, while the sweating secretion rate increased with age in the control group, it did not do so in the DS group. Once again this was due to female patients with DS, who did not show a significant increase of sweat secretion rate with age.ConclusionsSweat chloride concentrations were within the normal range in patients with DS and therefore seem to be a reliable tool for testing for CF in these patients. Interestingly, we found a reduced sweat secretion rate in the DS group. Whether the last one has a functional and clinical counterpart, possibly due to a disturbed thermoregulation in DS patients, requires further investigation.

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Extreme Hyperkeratotic Psoriasis in a Mongoloid

Rotchford¹

1961

Arch Dermatol

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A Clinicopathologic Study of the Skin in Mongolism

Cited by 20 publications

References 1 publication

Ichthyosis and Psoriasis in a Patient with Down Syndrome

Ichthyosis and Psoriasis in a Patient with Down Syndrome

Is sweat testing for cystic fibrosis feasible in patients with down syndrome?

Extreme Hyperkeratotic Psoriasis in a Mongoloid

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