Patrick H. Warnke, Andreas Humpe, Dirk Strunk, Sebastien Stephens, Frauke Warnke, Joerg Wiltfang, Katharina Schallmoser, Mohammad Alamein, Robert Bourke, Peter Heiner, Qin Liu
Abstract:The transplantation of human stem cells seeded on biomaterials holds promise for many clinical applications in cranio-maxillo-facial tissue engineering and regenerative medicine. However, stem cell propagation necessary to produce sufficient cell numbers currently utilizes fetal calf serum (FCS) as a growth supplement which may subsequently transmit animal pathogens. Human platelet lysate (HPL) could potentially be utilized to produce clinical-grade stem cell-loaded biomaterials as an appropriate FCS substitut…
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