A Clinical Study of One Hundred and Fifty Cases of Bronchial Asthma

Relationship among Asthma, Serum IgE Levels and Skin Test Sensitivity to Inhaled Allergens

“…Evidence has been obtained previously for the independent relationship of each of these factors with asthma [5,12,13,20]; but this is the first evidence showing that both together are associ ated with asthma. Our results were obtained by focusing on those asthmatics whose asthma had been diagnosed by a physician.…”

“…The form of asthma found most often in children and young adults occurs in association with IgE-mediated hypersensitivity to inhaled allergens and has been called 'atopic' or 'extrinsic' asthma. A 'nonatopic' or 'intrinsic' form of asthma occurs in the apparent absence of atopic sensitivity to aeroallergens [5,6]. The intrinsic form of asthma occurs most often in older adults [6].…”

Against all odds: anti-IgE for intrinsic asthma?

“…Although non-adherence to medication, incorrect use of inhalers and failure to eliminate tobacco smoke exposure are major reasons for uncontrolled asthma, which need to be addressed in clinical practice,28 29 there is currently no evidence that these issues are more prevalent in patients with intrinsic asthma than in patients with allergic asthma. After nearly a hundred years, the statement by Francis M. Rackemann from 1918 still holds true: ‘The treatment of intrinsic asthma is far from satisfactory’ 9. Patients with intrinsic asthma deserve that we explore this promising treatment option—against all odds.…”

“…As early as 1918, Francis M. Rackemann coined the term ‘intrinsic asthma’ for this group of patients 9. In the following decades, other terms such as ‘non-atopic asthma’, ‘non-allergic asthma’ or ‘infectious asthma’ were used to label these patients.…”

Neue Horizonte in der Prävention, Diagnostik und Therapie von Asthma

“…Hierzu zählt die Bestimmung der Bluteosinophilen-Konzentration mittels Differentialblutbild, einem seit mehr als 100 Jahren bekannten Asthmamarker [9], der durch diverse aktuelle Studien mit Biologika und durch seine Kostengünstigkeit, Robustheit und allgemeine Verfügbarkeit eine Renaissance erlebt hat [3]. Des Weiteren wird die Bedeutung der Reversibilitätsprüfung der Atemwegsobstruktion für die Diagnosestellung von Asthma in den aktuellen internationalen Empfehlungen ( www.ginasthma.com ) zwar stärker betont, andererseits gibt es aber zunehmende Hinweise darauf, dass auch Patienten mit chronisch-obstruktiver Lungenerkrankung (COPD) teils eine erhebliche Reversibilität der Atemwegsobstruktion zeigen [10].…”