1981
DOI: 10.1001/archderm.117.7.388
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A clinical screening program for topical chemotherapeutic drugs in psoriasis

Abstract: In this national, multicenter cooperative study, a standardized drug screening program was designed and evaluated to test the clinical effectiveness of 30 topically applied chemotherapeutic drugs to psoriasis. Appropriate concentrations and vehicles for topical administration were selected with regard to clinical testing consisted of a double-blind application of test agents to psoriatic plaques under occlusion daily for up to nine days. Drugs known to be topically active in psoriasis, eg, thiotepa, fluorourac… Show more

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Cited by 16 publications
(4 citation statements)
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“…2 ). It is noteworthy, for instance, that cycloheximide, an inhibitor of translation elongation [ 93 ], is surprisingly well tolerated and effective as a topical treatment for psoriasis [ 94 96 ].…”
Section: Discussionmentioning
confidence: 99%
“…2 ). It is noteworthy, for instance, that cycloheximide, an inhibitor of translation elongation [ 93 ], is surprisingly well tolerated and effective as a topical treatment for psoriasis [ 94 96 ].…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, Weinstein et al ., proved the beneficial therapeutic role of a potent topical AMDC activity inhibitor - methylglyoxal-bis-guanylhydrazone, which reduced the induration and erythema of the psoriatic plaques. [17]…”
Section: Discussionmentioning
confidence: 99%
“…Methotrexate, a folic acid antagonist, has been used systemically in the therapy of psoriasis to prevent hyperproliferation by its cytotoxic effect 9,10 . To reduce the hepatotoxic and hematologic adverse effects induced by orally administered methotrexate, and to adapt its use for the treatment of localized lesions, there has been considerable interest in the possibility of administering methotrexate topically 12–14,16–19 …”
Section: Discussionmentioning
confidence: 99%