A Clinical Database of Breast Cancer Patients Reveals Distinctive Clinico-pathological Characteristics: a Study From Central China

Wang, Lin-Wei; Yang, Guifang; Chen, Jiamei; Yang, Fang; Yuan, Jingping; Sun, Shengrong; Chen, Chuang; Hu, Ming-Bai; Li, Yan

doi:10.7314/apjcp.2014.15.4.1621

Cited by 14 publications

(17 citation statements)

References 28 publications

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“…A clinical database study conducted by Wang et al reported highest 90.1% of breast carcinoma was invasive ductal type similar to our study. 12 A study by Reddy et al observed 85.05% cases with duct cell carcinoma NOS type which correlates with our study. 13 Similar studies reported maximum frequency of breast cancer cases were of invasive ductal carcinoma type.…”

Section: Discussionsupporting

confidence: 92%

“…In contrast to our study, other studies have shown N0 as the most common stage followed by N1,N2,N3 respectively. 9,12,13,18 In addition, we found 70(62.5%) cases had lymphovascular invasion and 49(43.8%) cases had perineural invasion. A study by Song et al reported 54.2% MRM cases i.e.…”

Section: Well Differentiated I (3 -5) 14mentioning

confidence: 60%

“…In contrast to our study, lobular carcinoma was found to be second most frequent type of breast cancer. 12,15 We observed 3 cases of invasive papillary carcinoma, out of which one was male case. Similarly we identiied 3 cases of NST with apocrine differentiation and 2 each cases of apocrine, micropapillary, mucinous, NST with mucinous, NST mixed with lobular and micropapillary carcinoma type.…”

Section: Well Differentiated I (3 -5) 14mentioning

confidence: 97%

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Histopathological evaluation of carcinoma of breast

Pathak

Jha²,

Neupane³

et al. 2016

J Pathol Nep

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Background: Carcinoma of breast has become the major public health problem among females in developing as well as developed countries. In Nepal it comprises 6% of total cancers cases and often diagnosed at advanced stage. Surgical removal or modiied radical mastectomy (MRM) is the most commonly used tools for disease management. The objective of this study is to identify the clinical, macroscopic and microscopic features of MRM specimens. Materials and Methods:This prospective cross-sectional study was carried out at Department of Pathology, Bhaktapur Cancer Hospital, Bhaktapur, Nepal. Macroscopic and microscopic examination provided the tumor size, stage, grade, lymph node status, lympho-vascular invasion and perineural invasion. Data were collected and analyzed using SPSS 16. Results:The study comprised 112 breast cancer patients of which 109 (97.3%) were females and 3 (2.7%) were males. Invasive ductal carcinoma no speciic type was the most common type of breast carcinoma. (84 cases) accounting 75% of total cases. Carcinoma with medullary features was second most common (6 cases) comprising 5.4% cases followed by lobular, papillary, apocrine, mucinous and NST mixed types. Grade II tumors were most frequent grade observed in 76.79% cases followed by Grade I (12.50%) and Grade III (10.71%). Conclusion:As a conclusion invasive ductal carcinoma was the most common histological type breast cancer and the tumors were found at T2 and N3 stage i.e maximum at grade II. Our study provides prognostic signiicance of histo-pathological information in breast cancer management. ABSTRACT INTRODUCTIONBreast cancer is the most frequently occurring cancer among women in the developed as well as developing Pathak R 1 , Jha A 2 , Neupane PR 3 , Chalise S 2 , Basnyat AS 2 1 Department of Pathology, Nepal Medical college Teaching Hospital, Jorpati Kathmandu, Nepal. 2 Department of Pathology, Bhaktapur Cancer Hospital, Bhaktapur, Nepal 3 Department of Surgery, Bhaktapur Cancer Hospital, Bhaktapur, Nepal. countries and it has become the major public health problem worldwide with nearly 1.7 million newly diagnosed cases in 2012 representing 25% of all female cancers. 1,2 Among Nepalese women, breast cancer is the second most common type of cancer accounting 6% of total cancers in Nepal. 3 In Nepal, more than one quarter of the breast cancer is diagnosed in young female and many being diagnosed at an advanced stage with tumors showing more aggressive

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Section: Discussionsupporting

confidence: 92%

Section: Well Differentiated I (3 -5) 14mentioning

confidence: 60%

Section: Well Differentiated I (3 -5) 14mentioning

confidence: 97%

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Histopathological evaluation of carcinoma of breast

Pathak

Jha²,

Neupane³

et al. 2016

J Pathol Nep

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“…There are clear differences in clinicopathological characteristics of breast cancer between central China and Western countries. 4 The human epidermal growth factor receptor 2 gene (Her-2/neu) is a member of HER family and encodes a receptor of molecular mass 185 kDa. These receptors are single transmembrane proteins consisting of an intracellular tyrosine binding domain with various tyrosine phosphorylation sites 5,6 and an extracellular domain for ligand binding and a cytoplasmic tail.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of Her-2, p53, Ki-67 expression and clinicopathological characteristics of breast cancer in a cohort of northern China female patients

Zhang

et al. 2017

Bioengineered

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The objective was to study the relationship among Her-2, Ki-67, p53 expression and the clinicopathologic characteristics of breast cancer in the patients of northern China. Expression of Her-2, Ki-67, p53 and clinical characteristics of 260 breast cancer patients were retrospectively studied. Her-2 overexpression led to higher incidence rates of infiltrating ductal carcinoma and axillary lymph node metastasis, bigger diameters of the primary tumors, later pTNM staging, and a lower incidence rate of ductal carcinoma in situ (p < 0.05). High expression of ER and PR led to fewer patients classified histologically in higher grade (p D 0.001), while high expression of Ki-67 and p53 caused more patients classified histologically in higher grade (p D 0.001). In patients histologically classified in grade 1 and 2, the expression of Ki-67 and p53 was significantly (p D 0.001) higher, and the expression of ER and PR was significantly lower, in Her-2 positive patients than Her-2 negative patients. Breast cancer with Her-2 overexpression was more likely to recur and metastasize than Her-2 negative breast cancer. Higher coincidence of high expression of p53 and Ki-67 with Her-2 overexpression and more progressed tumors suggested that in addition to p53, Ki-67 might also be a prognostic biomarker of breast cancer.

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“…This represents a significant patient population and is strikingly different from age specific patient distribution reported in the West. Indeed it has been shown that breast cancer in women younger than 40 years of age is on the rise in Asian population (Thapa et al, 2013;Keramatina et al, 2014;Wang et al, 2014). In parts of the world with well developed screening programs, routine screening is not performed for women <40 years of age due to low incidence of cancer in this age group.…”

Section: Discussionmentioning

confidence: 99%

Comparison between Early and Late Onset Breast Cancer in Pakistani Women Undergoing Breast Conservative Therapy: is There any Difference?

Bhatti¹,

Jamshed²,

Khan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Early onset breast cancer is associated with poor outcomes but variable results have been reported. It is a significant problem in Pakistani women but remains under reported. Breast conservation plays an important role in surgical management of this younger patient group. The objective of this study was to determine the outcome of breast conservative therapy in patients with early onset breast cancer in our population and compare it with their older counterparts. Materials and Methods: A review of patients with invasive breast cancer who underwent breast conservation surgery at Shaukat Khanum Cancer Hospital from 1997 to 2009 was performed. Patients were divided into two groups i.e. Group I age ≤40 and Group II >40 years. A total of 401 patients with breast cancer were identified in Group I and 405 patients in Group II. Demographics, histopathological findings and receptor status of the two groups were compared. The Chi square test was used for categorical variables. Outcome was assessed on basis of 10 year locoregional recurrence free survival (LRRFS), disease free survival (DFS) and overall survival (OS) . For survival analysis Kaplan Meier curves were used and significance was determined using the Log rank test. Cox regression was applied for multivariate analysis. Results: Median follow up was 4.31 (0.1-15.5) years. Median age at presentation was 34.6 years (17-40) and 51.9 years (41-82) for the two groups. Groups were significantly different from each other with respect to grade, receptor status, tumor stage and use of neoadjuvant therapy. No significant difference was present between the two groups for estimated 10 year LRRFS (86% vs 95%) (p=0.1), DFS (70% vs 70%) (p=0.5) and OS (75% vs 63%) (p=0.1). On multivariate analysis, tumor stage was an independent predictor of LRRFS, DFS and OS. Conclusions: Early onset breast cancer is associated with a distinct biology but does not lead to poorer outcomes in our population.

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A Clinical Database of Breast Cancer Patients Reveals Distinctive Clinico-pathological Characteristics: a Study From Central China

Cited by 14 publications

References 28 publications

Histopathological evaluation of carcinoma of breast

Histopathological evaluation of carcinoma of breast

Comparative study of Her-2, p53, Ki-67 expression and clinicopathological characteristics of breast cancer in a cohort of northern China female patients

Comparison between Early and Late Onset Breast Cancer in Pakistani Women Undergoing Breast Conservative Therapy: is There any Difference?

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