2018
DOI: 10.1038/s41388-018-0369-y
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Abstract: Circular RNAs are a large group of noncoding RNAs that are widely expressed in mammalian cells. Genome-wide analyses have revealed abundant and evolutionarily conserved circular RNAs across species, which suggest specific physiological roles of these species. Using a microarray approach, we detected increased expression of a circular RNA circ-Dnmt1 in eight breast cancer cell lines and in patients with breast carcinoma. Silencing circ-Dnmt1 inhibited cell proliferation and survival. Ectopic circ-Dnmt1 increase… Show more

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Cited by 219 publications
(176 citation statements)
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“…Similarly, c-myc is translocated to the nucleus and stabilized by binding to circAmotl1, participating in tumorigenesis [34]. In addition, circDNMT1 could bind to p53 and AUF1 to facilitate their nuclear translocation, accelerating breast cancer progression via activating autophagy [106]. Furthermore, circAmotl1 could promote the nuclear translocation of STAT3 to stimulate wound healing [105].…”
Section: Protein Reservoirs or Interactions With Rbpsmentioning
confidence: 99%
“…Similarly, c-myc is translocated to the nucleus and stabilized by binding to circAmotl1, participating in tumorigenesis [34]. In addition, circDNMT1 could bind to p53 and AUF1 to facilitate their nuclear translocation, accelerating breast cancer progression via activating autophagy [106]. Furthermore, circAmotl1 could promote the nuclear translocation of STAT3 to stimulate wound healing [105].…”
Section: Protein Reservoirs or Interactions With Rbpsmentioning
confidence: 99%
“…Though breast cancer exhibits good prognosis, some breast cancer patients still suffer tumor progression. One of the emerging concepts to promote progression of breast cancer is autophagy [4,[8][9][10][11]. It is now known that the dysregulation of autophagy promotes progression of breast cancer.…”
Section: Discussionmentioning
confidence: 99%
“…hypoxia, starvation) and helps sustain their survival [7]. It has been reported that autophagy promotes survival, proliferation, metastasis, and invasion of BC cells via regulating autophagy associated genes and non-coding RNAs [4,[8][9][10][11][12]. However, the underlying mechanisms, especially non-coding RNAs, in regulating autophagy of BC progression are not yet fully elucidated.…”
Section: Introductionmentioning
confidence: 99%
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