A Circuit Simplification Mechanism Based on DNA Combinatorial Strands Displacement

Niu, Ying; Han, Feng; Zhang, Xuncai; Zhou, Zheng

doi:10.3233/fi-2019-1765

Cited by 2 publications

(1 citation statement)

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“…Besides, we improved the INHIBIT gate so that it can be used as a demultiplexer. In many multilayer DNA circuits [20], [34], [35], the outputs are mixed, and the individual strand can't be selected. The proposed demultiplexer has significant usages in signal selection.…”

Section: Discussionmentioning

confidence: 99%

DNA Logic Multiplexing Using Toehold-Mediated Strand Displacement

et al. 2020

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Since the discovery of the DNA Strand Displacement mechanism, researchers have implemented a lot of applications, such as DNA computing, DNA Circuits, Logic gates, and Chemical Reaction network. To achieve those functions, a well-designed system is essential, among which the toehold domains and migration domains play a vital role. In this paper, we designed three basic logic gates based on the toehold mediates DNA strand displacement mechanism, and utilized them to struct a three-layer multiplexer DNA logic circuit. However, the traditional INHIBIT gate annihilated all the inputs strands which obscure the multiplexer in further applications. Therefore, we improved the INHIBIT gate, so the desired input strand can be selected, and the corresponding output strand can be identified. Lastly, we adjusted the multiplexer and realized a cyclic DNA circuit. The simulation results verified the efficiency and reliability of our multiplexer DNA logic circuits. Our method has the ability in architecting complex DNA integrated circuits.INDEX TERMS DNA strand displacement, logic circuits, INHIBIT gate, demultiplexer.

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Section: Discussionmentioning

confidence: 99%

DNA Logic Multiplexing Using Toehold-Mediated Strand Displacement

et al. 2020

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Biochemical Logic Circuits Based on DNA Combinatorial Displacement

2020

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DNA, as an excellent nano-engineering material, contributes to a new computing model, namely, DNA computing. This model is a type of biological computing, which takes advantage of the high density and high parallelism of molecules. One of the current methods of implementing DNA computing is to construct DNA circuits, among which the toehold-mediated DNA strand displacement technique is an important method. The hybridization of toehold domains provides the start position and accelerates the branch migration process. Toehold-based DNA combinatorial displacement is a practical method for designing and implementing DNA circuits. In this paper, we designed and simulated a multiplexer using the DNA combinatorial displacement mechanism to verify its practicability. Additionally, we improved and optimized the existing logic INHIBIT gate by leveraging the DNA combinatorial displacement mechanism so that the DNA strands in the entire chemical reaction network (CRN) system are capable of coexisting in large quantities. Moreover, we applied this improvement to the demultiplexer. Our method provides more capabilities to larger and more complicated DNA integrated circuits. INDEX TERMS Combinatorial strand displacement, logic gate, CRN, DNA computing.

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A Circuit Simplification Mechanism Based on DNA Combinatorial Strands Displacement

Cited by 2 publications

References 0 publications

DNA Logic Multiplexing Using Toehold-Mediated Strand Displacement

DNA Logic Multiplexing Using Toehold-Mediated Strand Displacement

Biochemical Logic Circuits Based on DNA Combinatorial Displacement

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