A chiral stationary phase with special hydrophobic framework for ligand-exchange chromatography

Liquid chromatographic resolution of proton pump inhibitors including omeprazole on a ligand exchange chiral stationary phase

“…Ligand exchange CSPs have been extensively studied and used in resolving racemic analytes, which can be used as bidentate ligands such as ␣-amino acids, since the pioneering works of Davankov [15][16][17][18][19]. We also developed ligand exchange CSPs by bonding (S)-leucinol derivative, sodium N-[(S)-1-hydroxymethyl-3-methylbutyl]-N-undecylaminoacetate, or (R)-phenylglycinol derivative, sodium N-[(R)-2-hydroxy-1-phenylethyl]-N-undecylaminoacetate, to silica gel [20,21].…”