A cellular regulator of the niche: telocyte

The telocytes relationship with satellite cells: Extracellular vesicles mediate the myotendinous junction remodeling

“…The TC have already been associated with SC in skeletal striated muscle interstitium, their neighborhood relationship as well as their proximity have been demonstrated in vitro and in vivo (Popescu et al 2011; Manetti et al, 2019; Squecco et al 2021; Henrot et al 2023). As well as its association with the stem cell niche microenvironment (Rosa et al, 2021) as a regulatory cell (Babadag & Çelebi‐Saltik, 2023) and their contribution for differentiation and communication activity (Chaitow, 2017) as a progenitor cell for fibroblasts and myofibroblasts when faced with tissue repair and regeneration (Díaz‐Flores et al, 2014; Vannucchi et al, 2016; Díaz‐Flores et al, 2016).…”

Exosomes derived from ITGB1 modified Telocytes alleviates LPS-induced inflammation and oxidative stress through YAP1/ROS axis

“…Prior studies have highlighted distinct gene expression profiles in pulmonary TCs compared to other local cell types, indicating unique biological properties and behaviors [ 14 , 15 ]. TCs form three-dimensional network structures through Tps to contact with the homocytic or heterocytic cells, transmitting signaling molecules through pre-secretion and/or para-secretion, which enter the vascular, neural and endocrine systems through the growth and shedding of vesicles [ 16 ]. Thus, TCs can protect tissue from acute injury via cell–cell communication.…”

Telocytes and inflammation: A review

“…In this interaction, organelles, mRNA, microRNA, long-stranded noncoding RNA and genomic DNA are subsequently transferred to play a role in signal transmission. [3] In addition to signaling, TCs also participate in various physiological and pathological processes, such as the immune response, inflammatory response, angiogenesis and invasion and metastasis of cancer cells. Besides, TCs were shown to function as crucial components of the stem cell niche.…”