A cause of right ventricular dysfunction after cardiac operations

Bailey, Leonard L.; Ze-jian, Li; Schulz, Eloy; Roost, Heinrich; Yahiku, P Y; Linda, Loma

doi:10.1016/s0022-5223(19)37353-2

Cited by 48 publications

(19 citation statements)

References 10 publications

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“…212 These adhesions are the major cause of intestinal obstruction, 213 are responsible for up to 20% of infertility cases in women 214 and are thought to cause abdominal pain. [215][216][217] In the thorax, pleural loculation and adhesions can impair lung function and cardiac adhesions may have a deleterious effect on cardiac function 218 and/or result in decreased coronary artery bypass graft patency. 219 In addition, adhesions make the growing number of repeat surgical procedures difficult for the surgeon and hazardous for the patient.…”

Section: Coagulation and Fibrinolysismentioning

confidence: 99%

Mesothelial cells: Their structure, function and role in serosal repair

2002

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Mesothelial cells: Their structure, function and role in serosal repair MUTSAERS SE. Respirology 2002; 7: 171-191 The mesothelium is composed of an extensive monolayer of specialized cells (mesothelial cells) that line the body's serous cavities and internal organs. Traditionally, this layer was thought to be a simple tissue with the sole function of providing a slippery, non-adhesive and protective surface to facilitate intracoelomic movement. However, with the gradual accumulation of information about serosal tissues over the years, the mesothelium is now recognized as a dynamic cellular membrane with many important functions. These include transport and movement of fluid and particulate matter across the serosal cavities, leucocyte migration in response to inflammatory mediators, synthesis of pro-inflammatory cytokines, growth factors and extracellular matrix proteins to aid in serosal repair, release of factors to promote both the deposition and clearance of fibrin, and antigen presentation. Furthermore, the secretion of molecules, such as glycosaminoglycans and lubricants, not only protects tissues from abrasion, but also from infection and possibly tumour dissemination. Mesothelium is also unlike other epithelial-like surfaces because healing appears diffusely across the denuded surface, whereas in true epithelia, healing occurs solely at the wound edges as sheets of cells. Although controversial, recent studies have begun to shed light on the mechanisms involved in mesothelial regeneration. In the present review, the current understanding of the structure and function of the mesothelium and the biology of mesothelial cells is discussed, together with recent insights into the mechanisms regulating its repair.

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Section: Coagulation and Fibrinolysismentioning

confidence: 99%

Mesothelial cells: Their structure, function and role in serosal repair

2002

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“…During the regeneration of the mesothelium, these denuded areas may be covered by mesothelial cells from different sources, including activated mesothelial cells adjacent to the site of the injury and pre-existing floating PMCs [3,15,32]. When adhesions are formed on the pericardium, they may complicate contraction movements and flow, leading to several complications, including (in ascending order of severity) an increased risk of inadvertent injuries and reoperation [3], increased intraoperative bleeding [35], compression of the heart [36] and malfunction of ventricle contraction [37].…”

Section: Pericardiummentioning

confidence: 99%

Battling adhesions: from understanding to prevention

et al. 2019

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Adhesions represent a major burden in clinical practice, particularly following abdominal, intrauterine, pericardial and tendon surgical procedures. Adhesions are initiated by a disruption in the epithelial or mesothelial layer of tissue, which leads to fibrin adhesion sites due to the downregulation of fibrinolytic activity and an increase in fibrin deposition. Hence, the metabolic events involved in tissue healing, coagulation, inflammation, fibrinolysis and angiogenesis play a pivotal role in adhesion formation. Understanding these events, their interactions and their influence on the development of post-surgical adhesion is crucial for the development of effective therapies to prevent them. Mechanical barriers, antiadhesive agents and combination thereof are customarily used in the battle against adhesions. Although these systems seem to be effective at reducing adhesions in clinical procedures, their prevention remains still elusive, imposing the need for new antiadhesive strategies.

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“…(Ann Thorac Surg 2018;105:837-42) Ó 2018 by The Society of Thoracic Surgeons S urgical trauma to the pericardium and epicardium during open heart operations typically results in the formation of dense fibrovascular adhesions between the epicardium, the sternum, and the surrounding structures [1]. These adhesions may lead to heart constriction, right ventricular dysfunction, and even to coronary bypass graft occlusion [2][3][4]. During resternotomy, dense adhesions frequently contribute to increased surgical time, and they may lead to serious injury of the heart, lungs, or great vessels [5].…”

mentioning

confidence: 99%