A Case Report of Primary Breast Angiosarcoma: Clinical Presentation and Outcome After Adjuvant Radiotherapy

Altmışdörtoğlu, Özgür; Gökgöz, Mustafa Şehsuvar; Yalçinkaya, Ülviye; Andrieu, Meltem Nalca

doi:10.5152/ejbh.2020.4984

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…A few reports have indicated the increased efficacy of radiotherapy 12 . In a case report on a patient with primary breast angiosarcoma, although the tumor size was large and the margin was positive, the patient survived with a 66‐month disease‐free period after surgery plus radiotherapy 33 . Despite the limited value of the data as a reference due to the study scale, the multidisciplinary management of the patient is notable.…”

Section: Discussionmentioning

confidence: 99%

“… 12 In a case report on a patient with primary breast angiosarcoma, although the tumor size was large and the margin was positive, the patient survived with a 66‐month disease‐free period after surgery plus radiotherapy. 33 Despite the limited value of the data as a reference due to the study scale, the multidisciplinary management of the patient is notable. Feinberg et al compared the survival of patients with breast angiosarcoma (radiation‐associated) treated by sarcoma service and local hospitals.…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological characteristics and survival outcomes in patients with angiosarcoma of breast

Wang

et al. 2023

Cancer Medicine

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Background: Angiosarcoma of the breast is a rare malignancy. There are little data evaluating the survival and estimating the prognostic factors. The best surgical management and the role of systemic adjuvant therapy remain ill-defined.This study aimed to investigate the clinicopathological features, survival, and prognostic factors of breast angiosarcoma. Methods:The data on patients diagnosed with breast angiosarcoma were extracted from the Surveillance, Epidemiology, and End Results database . Univariate and multivariate Cox regression analyses were used to estimate the influential prognostic factors. The overall survival (OS) and disease-specific survival (DSS) of patients with breast angiosarcoma were evaluated.Results: This study included 656 patients diagnosed with breast angiosarcoma between 1975 and 2016. The 5-year OS rate of all patients was 44.9% (95% CI 40.8-49.0). In both OS and DSS, Kaplan-Meier survival analyses revealed significant differences for both OS and DSS according to age, year at diagnosis, laterality, grade, and stage (all log-rank p < 0.05). Multivariate analysis suggested that lesions of the right breast, poor differentiation, and advanced stage were independent risk factors for OS or DSS (all p < 0.05). Older age was a risk factor in OS, but was protective in DSS. In primary breast angiosarcoma, age, laterality, grade, and stage were independent prognostic factors in OS and DSS (all p < 0.05).Mastectomy was also a risk factor in DSS (p = 0.034). The proportion of patients with grade III and regional disease was larger in the mastectomy group. Conclusion:Angiosarcoma of the breast had a poor prognosis. In our study, age, laterality, histologic grade, and stage were identified as significant prognostic factors. Why patients with angiosarcoma of the right breast had a worse prognosis remains equivocal. Mastectomy was adopted more often by surgeons in this cohort study for patients with advanced primary breast angiosarcoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics and survival outcomes in patients with angiosarcoma of breast

Wang

et al. 2023

Cancer Medicine

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“…A recent study has shown that cytotoxic chemotherapies, in particular anthracycline-based regimens and taxanes can produce significant responses to therapy in a subset of patients (66). Adjuvant radiotherapy could be used to reduce the incidence of locoregional recurrence (67). However, the disease is usually resistant to currently available chemotherapy and radiotherapy, which may not alter the poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Primary breast angiosarcoma: A case report

Qian

Chen

et al. 2023

Front. Surg.

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BackgroundPrimary breast angiosarcoma (PBA) is a rare sarcoma, accounting for only 0.04% of all breast malignancies, with a difficult diagnosis and a poor prognosis. Mastectomy is the standard treatment, and the role of adjuvant treatment (chemotherapy and/or radiotherapy following surgery) remains uncertain with very few studies.Case PresentationWe report the case of a 17-year-old female patient who presented with a right breast lump that had rapidly increased in size and was hemorrhaging. She was diagnosed with breast angiosarcoma by needle biopsy and pathological evaluation. However, the mass showed a quick tendency to bleed during biopsies. After that, we performed angiography and tumor vascular embolization. The patient underwent a mastectomy followed by adjuvant chemotherapy.ConclusionTumor vascular embolization reduced the surgical risk of PBA with hemorrhage complications. Postoperative therapeutic roles still need further exploration and verification.

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A Case Report of Primary Breast Angiosarcoma: Clinical Presentation and Outcome After Adjuvant Radiotherapy

Cited by 2 publications

References 18 publications

Clinicopathological characteristics and survival outcomes in patients with angiosarcoma of breast

Clinicopathological characteristics and survival outcomes in patients with angiosarcoma of breast

Primary breast angiosarcoma: A case report

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