A Case Report of Adenovirus-Related Acute Interstitial Nephritis in a Patient With AIDS

Mazoyer, Elodie; Daugas, Éric; Verine, Jérôme; Pillebout, Évangéline; Mourad, Nathalie; Molina, Jean‐Michel; Glotz, Denis

doi:10.1053/j.ajkd.2007.08.025

Cited by 14 publications

(4 citation statements)

References 22 publications

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“…240 The GI tract is involved in more than 90% of HIV patients with AdV infections, but most patients are asymptomatic or have mild symptoms (e.g., diarrhea). 239 AdV UTIs in HIV-infected patients may cause acute interstitial nephritis 241 and HC. 79 Species D is associated with GI infection, whereas UTIs are usually caused by types B or D. 239 AdV (particularly types 1, 2, 3) may cause fatal cases in HIV-infected patients.…”

Section: Specific Patient Populations At Riskmentioning

confidence: 99%

Adenovirus: Epidemiology, Global Spread of Novel Types, and Approach to Treatment

Lynch

Kajon

2021

Semin Respir Crit Care Med

129

187

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Adenoviruses (AdVs) are DNA viruses that typically cause mild infections involving the upper or lower respiratory tract, gastrointestinal tract, or conjunctiva. Rare manifestations of AdV infections include hemorrhagic cystitis, hepatitis, hemorrhagic colitis, pancreatitis, nephritis, or meningoencephalitis. AdV infections are more common in young children, due to lack of humoral immunity. Epidemics of AdV infection may occur in healthy children or adults in closed or crowded settings (particularly military recruits). The vast majority of cases are self-limited. However, the clinical spectrum is broad and fatalities may occur. Dissemination is more likely in patients with impaired immunity (e.g., organ transplant recipients, human immunodeficiency virus infection). Fatality rates for untreated severe AdV pneumonia or disseminated disease may exceed 50%. More than 100 genotypes and 52 serotypes of AdV have been identified and classified into seven species designated HAdV-A through -G. Different types display different tissue tropisms that correlate with clinical manifestations of infection. The predominant types circulating at a given time differ among countries or regions, and change over time. Transmission of novel strains between countries or across continents and replacement of dominant viruses by new strains may occur. Treatment of AdV infections is controversial, as prospective, randomized therapeutic trials have not been done. Cidofovir has been the drug of choice for severe AdV infections, but not all patients require treatment. Live oral vaccines are highly efficacious in reducing the risk of respiratory AdV infection and are in routine use in the military in the United States but currently are not available to civilians.

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Section: Specific Patient Populations At Riskmentioning

confidence: 99%

Adenovirus: Epidemiology, Global Spread of Novel Types, and Approach to Treatment

Lynch

Kajon

2021

Semin Respir Crit Care Med

129

187

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“…There are isolated reports of adenovirus-related urological and renal disease in this population. Mazoyer et al recently described a 34 year old white male with AIDS and a CD4 count of 0 cells/μL who presented with gross hematuria, mild azotemia, and non-nephrotic proteinuria (71). Urine culture and urine PCR were positive for adenovirus.…”

Section: Adenovirusmentioning

confidence: 99%

Viruses and Kidney Disease: Beyond HIV

Waldman

Marshall

Whitby

et al. 2008

Seminars in Nephrology

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HIV-infected patients may acquire new viral co-infections; they may also experience the reactivation or worsening of existing viral infections, including active, smoldering, or latent infections. HIVinfected patients may be predisposed to these viral infections due to immunodeficiency or to risk factors common to HIV and other viruses. A number of these affect the kidney, either by direct infection or by deposition of immune complexes. In this review we discuss the renal manifestations and treatment of hepatitis C virus, BK virus, adenovirus, cytomegalovirus, and parvovirus B19 in patients with HIV disease. We also discuss an approach to the identification of new viral renal pathogens, using a viral gene chip to identify viral DNA or RNA.

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“…In one case, rituximab therapy resulted in fulminant adenoviral hepatitis [32]. Adenovirus nephritis may be accompanied by hemorrhagic cystitis [3,[9][10][11][12][13][14][15]18,[33][34][35][36][37][38][39][40][41][42]. Data on 10 single patients (five men/five women) including four children with adenovirus nephritis after RT have been published (Table 1) [9][10][11][12][13][14][43][44][45][46]; two patients had combined kidney-pancreas transplantation and in these cases the pancreas allograft was not involved.…”

mentioning

confidence: 99%

“…Eight of the 11 cases (including the patient covered in this report) were treated during the past 5 years. Two cases of adenoviral nephritis ( Table 2) involved immunocompetent individuals and both had good outcome [16,47]; two HIV-infected patients with adenovirus nephritis died from other opportunistic infections [33,48]. Six articles on adenovirus nephritis in SC recipients including three case reports had been published; one series also included chemotherapy patients [3,34,[49][50][51][52][53].…”

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confidence: 99%