A Case of Wernicke-Korsakoff Syndrome Treated 1 Year After the Onset of Symptoms

Bilici, Rabia; Sarıdogan, G.; Turan, Cetin; Göncü, Tuğba; Akdur, Ozgur; Domaç, Füsun Mayda

doi:10.4088/pcc.15l01801

Cited by 1 publication

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“…Nutritional deficits associated with mammillary body volume loss has been seen in reduced vitamin B intake or absorption, in particular thiamine. The volume loss and thiamine deficiency has been accompanied with anterograde memory loss in Korsakoff's syndrome, which is associated with chronic alcoholism (30). In animal models, thiamine deficiency has led to extensive damage to the mammillary bodies correlating with worse performance on memory and spatial tasks (31).…”

Section: Discussionmentioning

confidence: 99%

Reduced brain mammillary body volumes and memory deficits in adolescents who have undergone the Fontan procedure

et al. 2019

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Background: Adolescents with single ventricle heart disease (SVHD), who have undergone the Fontan procedure, show cognitive/memory deficits. Mammillary bodies are key brain sites that regulate memory; however, their integrity in SVHD is unclear. We evaluated mammillary body (MB) volumes and their associations with cognitive/memory scores in SVHD and controls. Methods: Brain MRI data were collected from 63 adolescents (25 SVHD; 38 controls) using a 3.0-Tesla MRI scanner. Cognition and memory were assessed using Montreal Cognitive Assessment (MoCA) and Wide Range Assessment of Memory and Learning 2. MB volumes were calculated and compared between groups (ANCOVA, covariates: age, sex, and total-brain-volume [TBV]). Partial correlations and linear regression were performed to examine associations between volumes and cognitive scores (covariates: age, sex, and TBV). Results: SVHD group showed significantly lower MoCA and WRAML2 scores over controls. MB volumes were significantly reduced in SVHD over controls. After controlling for age, sex, and Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:

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Section: Discussionmentioning

confidence: 99%