2014
DOI: 10.1111/jcpt.12191
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Abstract: Summary What is known and objective Drug‐induced liver injury (DILI) is a leading cause of acute liver failure in developed countries. Hepatotoxicity is a well‐recognized adverse effect associated with synthetic oestrogens, which can cause cholestasis. The current report describes ethinyloestradiol (EE2)‐associated highly unusual adverse effects of autoimmune hepatitis (AIH) and microvesicular steatosis (MS). DILI that fulfils the criteria for AIH is referred to as drug‐induced autoimmune hepatitis (DIAIH). MS… Show more

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Cited by 6 publications
(1 citation statement)
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“…The binding of EDCs to these and other receptors, as well as steroidogenic enzymes, can perturb normal physiological processes. Health effects attributed to EDCs include reproductive dysfunction (e.g., distorted male/female sex ratios in fish, elevated or reduced hormone levels, diminished fertility, and male and female reproductive tract abnormalities) [ 21 , 22 ]; premature puberty [ 23 ]; neurological [ 24 , 25 ] and behavioral [ 26 , 27 , 28 , 29 ] complications; immune dysregulation [ 30 , 31 ]; cancer [ 32 , 33 , 34 , 35 , 36 ] and metabolic diseases [ 30 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. EDCs include personal care products, plasticizers, detergents, insecticides, and pharmaceuticals.…”
Section: Introductionmentioning
confidence: 99%
“…The binding of EDCs to these and other receptors, as well as steroidogenic enzymes, can perturb normal physiological processes. Health effects attributed to EDCs include reproductive dysfunction (e.g., distorted male/female sex ratios in fish, elevated or reduced hormone levels, diminished fertility, and male and female reproductive tract abnormalities) [ 21 , 22 ]; premature puberty [ 23 ]; neurological [ 24 , 25 ] and behavioral [ 26 , 27 , 28 , 29 ] complications; immune dysregulation [ 30 , 31 ]; cancer [ 32 , 33 , 34 , 35 , 36 ] and metabolic diseases [ 30 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. EDCs include personal care products, plasticizers, detergents, insecticides, and pharmaceuticals.…”
Section: Introductionmentioning
confidence: 99%