A Case of Sudden Deafness Probably Due to Antithymocyte Globulin Treatment

Vural, Abdülgaffar; Önder, Turgut; Tanboğa, Hikmet

doi:10.1159/000188487

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…To date, there is only one published case report suggesting an association of chronic hearing impairment after transplantation with immunosuppression 17. In contrast, a number of case reports have presumed an association of sudden hearing loss with a variety of immunosuppressants 12–16. In nearly all of them, dose correction or switching led to full hearing recovery.…”

Section: Discussionmentioning

confidence: 99%

“…Up to now, only few cases reported hearing loss in adults after organ transplantation receiving different immunosuppressants (cyclosporine, tacrolimus, OKT3, antithymocyte globulin) 12–17. We conducted a single‐center study including all adult patients alive after liver transplantation to evaluate their subjective hearing status and detect hearing impairment.…”

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confidence: 99%

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A new side effect of immunosuppression: High incidence of hearing impairment after liver transplantation

et al. 2006

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Little is known about hearing impairment in patients after organ transplantation. We conducted a single-center study to evaluate hearing impairment in patients after orthotopic liver transplantation (OLT). A questionnaire was sent to 695 adult patients after OLT to assess characteristics and course of auditory impairment. Risk factors such as ototoxic drugs were taken into consideration. Clinical follow-up, including immunosuppressive therapy, was analyzed in detail. The questionnaire was completed by 521 patients (75%). Hearing impairment was reported by 184 patients (35%). A total of 43 patients (8%) suffered from hearing abnormalities prior to OLT. The remaining 141 patients (27%) developed hearing impairment after transplantation. Main problems were hearing loss (52%), tinnitus (38%), and otalgia (30%). There was no association of post-OLT hearing disorders with age or known risk factors. In 43% of patients, onset of hearing impairment was within 2 yr post-OLT. Hearing loss was positively associated with tacrolimus immunosuppression in univariate (P Ͻ 0.05) and multivariate analysis (P Ͻ 0.02). Patients using a hearing aid received tacrolimus more frequently than cyclosporine (P Ͻ 0.05). In conclusion, subjective hearing impairment is frequent in patients after OLT and contributes to post-OLT morbidity. Calcineurin inhibitor-related neurotoxicity appears as a possible mechanism. Further prospective investigations with objective hearing tests are necessary to confirm these results and to evaluate the role of immunosuppression. Liver Transpl 12: 411-415, 2006.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%