A Case of Strangulation of the Intestine Due to a Transmesosigmoid Hernia

Sasaki, Yoshiyuki; Kunieda, Kenjiro; Sano, Bun; Tanaka, Chihiro; Nagao, Narutoshi; Kawai, Masahiko

doi:10.3919/jjsa.70.2403

Cited by 1 publication

(1 citation statement)

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“…Thyroid hormone induces the hepatic expression of hydroxymethylglutaryl coenzyme A reductase, which results in increased cholesterol synthesis 24 . Since LDL contains 65% TC 25 , the trends of alterations in serum TC and LDL levels were consistent. Thyroid hormone also appears to play a role in the regulation of hepatic lipase and lipoprotein lipase activity 13 .…”

Section: Discussionmentioning

confidence: 62%

Alteration of Lipid Profile Between Subclinical Hypothyroidism and Well-Matched Controls: A Meta-Analysis

et al. 2023

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In previous studies, subclinical hypothyroidism (SCH) has been associated with altered lipid profiles. However, since the discrepancy between these study results may reside in the great heterogeneity of the populations studied, this relationship is controversial. This study aimed to explore the changes in total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c) between subclinical hypothyroidism (SCH) and well-matched euthyroid (EU) groups. Multiple databases were searched for publications before December 1, 2021, including cross-sectional studies on the association between SCH and lipid profile matched by age, gender, and BMI. Twenty-five articles with 3347 participants were included for meta-analysis. The results showed that the TC, TG, and LDL-c levels of the SCH groups were higher than the EU groups (TC, SMD = 0.49, 95% CI 0.27, 0.71, p < 0.001) (TG, SMD = 0.43, 95% CI 0.21, 0.64, p < 0.05 ) (LDL-c, SMD = 0.75, 95% CI 0.46, 1.03, p < 0.001 ). The HDL-c levels of the SCH group were lower than the control group (SMD = -0.53, 95% CI -0.81, -0.25, p < 0.05). SCH has a larger impact on LDL-c than the other three indicators. After subgroup analyses, there was a larger impact on lipid alteration in the subgroup of TSH > 10 μIU/ml, especially on LDL-c. This study found SCH was associated with altered lipid profiles. Appropriate clinical treatment may be needed to prevent dyslipidemia and related diseases.

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Section: Discussionmentioning

confidence: 62%