A Case of Sialadenoma Papilliferum of the Esophagus

Abstract

Sialadenoma papilliferum of the esophagus is an extremely rare benign tumor that derives from the submucosal gland duct of the minor salivary gland. A 45-year-old man underwent upper gastrointestinal series. A 13 mm diameter esophageal polyp was suspected in the mid esophagus. Endoscopy examination revealed a pedunculated polyp arising from the posterior wall of the esophagus. The head of the polyp was covered with exudate and was slightly nodular but the pedicle had normal mucosa. We performed endoscopic mucosal resection (EMR) and the histological examination of the polyp showed that it was compatible with sialadenoma papilliferum of the esophagus.

Submucosal gland neoplasms of the esophagus: an update and review

“…All these different cells could be detected in one case [ 8 ]. In rare circumstance, the surface of SGDA has a papillary structure covered by stratified squamous epithelium, reminiscent of sialadenoma papilliferum [ 9 , 10 ]. According to the histological features, we proposed the diagnostic criteria of esophageal SGDA that include: (1) multiple glands or cysts that arranged as lobular structure and covered by two layers of cells, the inner luminal epithelial cells and the outer basal or myoepithelial cells; (2) presence of the multilayered epithelium and papillary structures in those glands or cysts, without marked cytologic atypia; (3) lymphocytic aggregation, and atrophy or disappearance of the concomitant acini (Fig.…”