A Case of Severe Calciphylaxis Seen on Three-Phase Bone Scan

Cosmin, Adrian; Soudry, Gabriel

doi:10.1097/01.rlu.0000182282.66664.64

Cited by 10 publications

(6 citation statements)

References 5 publications

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“…A noninvasive and less painful alternative for identifying deeper breast lesions is sonography, on which diffuse parenchymal edema, skin thickening, and numerous echogenic foci with posterior acoustic shadowing suggestive of large calcifications may be visualized (53). Recently, nuclear bone scans have shown promise as a diagnostic tool for calciphylaxis (35,54–57). Specifically, bone scans are capable of detecting subcutaneous calcium deposits regardless of the locations of the superficial lesions.…”

Section: Workupmentioning

confidence: 99%

Calciphylaxis

Peng

2011

Dermatologic Therapy

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Calciphylaxis is a disease in which metastatic calcification affects small- and medium-sized vessels resulting in significant dermatologic manifestations. Lesions typically occur over areas of high fat content and progress to black leathery eschars. Calciphylaxis is associated with intense pain and markedly increased risk of infection, often leading to sepsis requiring hospitalization. Diagnosis is made by clinical history and skin biopsy. Management of calciphylaxis is interdisciplinary, emphasizing factors such as primary prevention, proper wound care, pain control, and hormone and mineral balance. Although calciphylaxis carries a high mortality rate, symptomatic treatment has shown promise as a method for controlling disease progression.

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Section: Workupmentioning

confidence: 99%

Calciphylaxis

Peng

2011

Dermatologic Therapy

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“…The search terms were limited to the English-language literature between the years 1980 and 2006. The review revealed only two recent case reports [8,10] and an article by Fine et al [9] published in 2002.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 93%

“…The areas of abnormal uptake in the bone scan usually corresponded to the sites of obvious disease as per clinical examination. In the case report by Cosmin and Soudry [10], a threephase bone scan displayed abnormal uptake only in the bilateral pretibial regions, where the patient had presented with cellulitis and soft tissue calcifi cation Fig. 4 Dual intensity whole-body 99mTc-methylene diphosphonate (MDP) bone scan demonstrating high background activity and poor defi nition of the skeleton and kidneys.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 95%

Calciphylaxis and bone scintigraphy: case report with histological confirmation and review of the literature

et al. 2007

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We present a patient with a history of end-stage renal disease, who developed skin lesions in the bilateral calves a month after the initiation of hemodialysis. The lesions were biopsied, and the histological findings were consistent with a diagnosis of calciphylaxis. The patient had a baseline pretreatment bone scan that showed extensive systemic disease. The patient died 20 days after the imaging study. A review of the literature on bone scans and calciphylaxis is presented.

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“…muscle groups of the shoulders and thighs, possibly related to chronic subclinical trauma. 118 Calciphylaxis, often associated with tertiary hyperparathyroidism, results in systemic medial calcification of the arteries, most commonly leading to ischemia of dermis and subcutaneous fat, 119 with typically intense uptake noted on bone scintigraphy [120][121][122][123] ( Fig. 6).…”

Section: Figurementioning

confidence: 99%