A Case of SAPHO Syndrome With Diffuse Sclerosing Osteomyelitis of the Mandible Treated Successfully With Prednisolone and Bisphosphonate

Hatano, Hiroko; Shigeishi, Hideo; Higashikawa, Koichiro; Shimasue, Hiroshi; Nishi, Hisao; Oiwa, Hiroshi; Shindo, Hajime; Takechi, Masaaki; Ohge, Hiroki; Kamata, Nobuyuki

doi:10.1016/j.joms.2011.04.010

Cited by 27 publications

(24 citation statements)

References 17 publications

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“…Therefore, treatments are based on published case reports and small case series with expert opinion. NSAIDs and analgesics are first line agents, though therapeutic effects are limited and approximately 50% of SAPHO patient would continue to suffer from pain and disease exacerbation [11,12]. Alternatively, disease-modifying anti-rheumatic drugs (DMARDs) have had some success in some while ineffective in others.…”

Section: Discussionmentioning

confidence: 99%

SAPHO Syndrome: A Chameleon in Medical Diseases

2015

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SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a unique condition. Its rarity and variable presentation consummate its place within an elite group of elusory diagnosis. As a result, the diagnosis of SAPHO syndrome is often delayed by many years and is associated with increased medical cost, human suffering and worsened outcome. We present an atypical presentation of the SAPHO syndrome exhibiting an insidious onset of left hip pain with proximal femoral diaphyseal sterile osteitis along with severe weight loss that remained undiagnosed for over 5 years. We searched PubMed using SAPHO syndrome, unique SAPHO, SAPHO case study, SAPHO, CMRO and diaphysis as keywords for our literature review. The purpose of this case report is to emphasize a need for vigilance, timely recognition and prompt treatment. We further recommend aggressive early therapy for swift symptom resolution and improved medical outcome.

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Section: Discussionmentioning

confidence: 99%

SAPHO Syndrome: A Chameleon in Medical Diseases

2015

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“…It was reported that oral bisphosphonates are safer and more practical than intravenous bisphosphonates. Hatano et al [23] reported that combined treatment with corticosteroid and oral bisphosphonates was effective for DSOM associated with SAPHO syndrome. However, the use of oral bisphosphonate as monotherapy for DSOM associated with SAPHO syndrome has not been reported.…”

Section: Discussionmentioning

confidence: 99%

A case of diffuse sclerotic osteomyelitis of the mandible associated with SAPHO syndrome successfully treated with an oral bisphosphonate

Ikeda

Yamachika

Matsumura

et al. 2015

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathol

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“…Ainsi, les AINS représentent le traitement de base [4]. Les corticoïdes peuvent aussi être intéressants d'un point de vue symptomatique [10,21]. Les injections de toxines botuliques dans les muscles masséters peuvent être indiquées pour diminuer les contraintes sur l'articulation temporo-mandibulaire et soulager les douleurs [7].…”

Section: Le Rôle De L'odontologiste Dans Le Diagnostic Du Syndrome Saphounclassified

Le rôle de l’odontologiste dans le cadre du syndrome SAPHO : cas cliniques et revue de la littérature des signes oro-faciaux

Sturque

Denis

Guillerminet

et al. 2016

Med Buccale Chir Buccale

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Résumé -Introduction :Le syndrome SAPHO est une affection rare associant des signes ostéo-articulaires et cutanés. C'est une maladie douloureuse et invalidante atteignant plus fréquemment les femmes que les hommes. Les signes cliniques au niveau de la sphère oro-faciale sont rarement évoqués. Observations : Les signes cliniques oro-faciaux évocateurs de ce syndrome ont été rapportés chez un homme de 50 ans et la prise en charge odontotologique d'une femme de 39 ans atteinte d'un syndrome SAPHO est décrite. Discussion : L'odontologiste peut être amené à diagnostiquer un syndrome SAPHO devant certains signes oro-faciaux évocateurs qui font l'objet d'une revue de la littérature. De plus, il apporte sa contribution dans la prise en charge des lésions oro-faciales liées directement au syndrome ou indirectement mais dont le traitement nécessite des précautions particulières ainsi que par la recherche de foyers infectieux avant l'instauration des traitements du syndrome SAPHO. Conclusion : L'odontologiste doit jouer un rôle actif dans la prise en charge du syndrome SAPHO tant sur le versant diagnostique que thérapeutique.Abstract -The role of the dentist in SAPHO syndrome: case reports and literature review of orofacial manifestations. Introduction: SAPHO syndrome is a rare disorder combining osteoarticular and cutaneous signs. It is a painful and disabling disease, which affects women more frequently than men. Orofacial manifestations are rarely reported. Observation: The first case presents orofacial manifestations suggestive of SAPHO syndrome involving a 50-year-old patient, and the second case shows a 39-year-old woman affected by SAPHO syndrome treated in a department of dentistry. Discussion: Certain orofacial manifestations can suggest a diagnosis of SAPHO syndrome, which are the subject of a literature review. The dentist contributes to the management of the orofacial manifestations directly linked to the syndrome or indirectly, for which the treatment requires particular precautions and searching for foci of infection before the commencement of the SAPHO syndrome treatments. Conclusion: The dentist must be allowed to play an active role in the management of SAPHO syndrome, in both the diagnostic and therapeutic aspects.

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A Case of SAPHO Syndrome With Diffuse Sclerosing Osteomyelitis of the Mandible Treated Successfully With Prednisolone and Bisphosphonate

Cited by 27 publications

References 17 publications

SAPHO Syndrome: A Chameleon in Medical Diseases

SAPHO Syndrome: A Chameleon in Medical Diseases

A case of diffuse sclerotic osteomyelitis of the mandible associated with SAPHO syndrome successfully treated with an oral bisphosphonate

Le rôle de l’odontologiste dans le cadre du syndrome SAPHO : cas cliniques et revue de la littérature des signes oro-faciaux

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