A case of refractory Kimura disease with a buccal bulky mass successfully treated with low-dose cyclosporine A: Report and review of the literature

Miki, Haruka; Tsuboi, Hiroto; Kaneko, Shunta; Takahashi, Hiroyuki; Yokosawa, Masahiro; Asashima, Hiromitsu; Hirota, Tomoya; Hagiwara, Shinji; Umeda, N.; Kondo, Yuya; Nishimura, Bungo; Sugano, Masato; Matsumoto, Isao; Sumida, Takayuki

doi:10.1016/j.alit.2015.10.008

Cited by 18 publications

(14 citation statements)

References 12 publications

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“…Successful cases have been reported by applying surgery, radiotherapy, and chemotherapy (14). According to some case reports, different medications, such as cyclosporine, tacrolimus, mycophenolate mofetil, and loratadine (15)(16)(17), have been used in the treatment of KD with responses ranging from mild improvement to complete remission or even cure of the disease. As KD is benign, surgical resection does not spread lesions, but helps to reduce lumps and benefits diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Clinical analysis of Kimura’s disease in 24 cases from China

Zhang

Sun

et al. 2019

Preprint

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Background: We reviewed details of Chinese Kimura’s disease (KD) cases. A full clinical analysis was subsequently performed to improve the accuracy of clinical diagnosis and treatment of KD. Methods: A total of 24 patients with pathologically confirmed KD treated between March 2008 and March 2018 were reviewed retrospectively for clinical and histopathological analysis. Results: In the 24 KD cases, 20 were male and 4 were female with the age of onset ranging from 5 to 65 years. Lesion diameter ranged from 0.6 cm to 7 cm with unilateral involvement being more popular (79%). Imaging examination had a high detection rate for KD involving the parotid gland and subcutaneous but had low specificity. Microscopic analysis indicated that KD mainly involved subcutaneous soft tissue and lymph nodes. The prominent feature of lymphoid tissue was germinal center hyperplasia surrounded by several lobules associated with hyperplastic vascular structures. Out of the 24 patients, 11 experienced recurrence of disease after treatment (surgical resection: 46.2%, surgical resection followed by oral corticosteroids: 71.4% and surgical resection combined with radiotherapy: 0%). Conclusions: Our analysis revealed clinical, imaging, and histological characteristics of KD. A better understanding of the disease will help clinicians reduce misdiagnosis and improve the diagnostic rate upon patient first clinical visit.

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Section: Discussionmentioning

confidence: 99%

Clinical analysis of Kimura’s disease in 24 cases from China

Zhang

Sun

et al. 2019

Preprint

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“…[ 1 – 7 ] It usually presents in young Asian men with painless soft-tissue masses in the head and neck region. [ 1 – 7 ] However, the occurrence of Kimura disease in the oral cavity, as seen in this patient, is extremely rare. [ 1 , 4 , 7 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 – 7 ] However, the occurrence of Kimura disease in the oral cavity, as seen in this patient, is extremely rare. [ 1 , 4 , 7 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 , 4 ] There are only a few reports of Kimura disease in the oral cavity. [ 1 , 4 , 7 ] Herein, we report an extremely rare case of Kimura disease in the buccal region in a 16-year boy with nephrotic syndrome.…”

Section: Introductionmentioning

confidence: 99%

“…Kimura disease is a rare benign, chronic inflammatory disorder that typically presents with slowly enlarging, nontender, subcutaneous swellings in the head and neck region. [ 1 – 7 ] The majority of these lesions occur in the parotid glands, submandibular glands, or lymph nodes of the neck. [ 1 , 4 ] There are only a few reports of Kimura disease in the oral cavity.…”

Section: Introductionmentioning

confidence: 99%

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Kimura disease of buccal region in a pediatric patient with nephrotic syndrome

Lee

Kim²,

Yang

et al. 2017

Medicine

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Rationale:Kimura disease is a rare benign, chronic inflammatory disorder that typically presents with slowly enlarging, nontender, subcutaneous swellings in the head and neck region. The occurrence of Kimura disease in the oral cavity is extremely rare.Patient concerns:A 16-year-old boy presented with a complaint of a right painless buccal mass of 3 years’ duration.Diagnosis:The patient had been diagnosed with nephrotic syndrome and treated with corticosteroid at the age of 5 years.Outcomes:We report an extremely rare case of Kimura disease of the buccal region in a 16-year-old boy with nephrotic syndrome.Lesson:We controlled Kimura disease and nephrotic syndrome in this patient by using a combination of surgical resection of the buccal mass and systemic steroid therapy.

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