A case of primary osteosarcoma of the breast probably related to fibroadenoma

Nagano, Akiko; Komo, Toshiaki; Nagatani, Satoru; Tahara, Ko; Hotei, Hiroshi; Maeda, Yoshiyuki; Sasaki, Nozomu

doi:10.3919/jjsa.73.1367

Cited by 2 publications

(1 citation statement)

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“…The local recurrence rate was 67% for patients treated with local excision (a biopsy or tylectomy) and 11% for those treated with mastectomy [ 1 ]. As adjuvant chemotherapy, methotrexate and bleomycin, cyclophosphamide, CDDP, doxorubicin, and ifosfamide have been shown to be effective, as well as a therapy for osteosarcoma of the bone [ 6 , 10 , 11 ]. However, no standard regimen has been established for extraskeletal osteosarcoma.…”

Section: Case Presentationmentioning

confidence: 99%

A case of primary extraskeletal osteosarcoma of the breast

et al. 2018

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BackgroundPrimary sarcomas of the breast are rare and account for less than 1% of all primary breast malignancies. We experienced a case of extraskeletal osteosarcoma of the breast that had a unique clinical course and remarkable findings of mammography and magnetic resonance imaging (MRI). A review of the case reports published in the past few decades showed no reports of a case in which a calcified lesion was followed up three different times on mammography, making this a valuable case report.Case presentationA 52-year-old woman noticed a right breast mass and underwent a breast examination. Mammography showed a 1.5-cm coarse calcified lesion in the upper outer portion of the right breast. Because fine-needle aspiration (FNA) revealed no suspicion of malignancy, she was followed up. Sixteen months later, the tumor grew progressively to 4.5 cm in size with new calcifications that were fine and irregular in shape and density surrounding an enlarged, coarse calcified lesion. Contrast-enhanced magnetic resonance imaging (MRI) showed a high signal intensity in the periphery of the tumor. Extirpation of the tumor was indicated. The pathological findings were extraskeletal osteosarcoma. She underwent additional resection and latissimus dorsi flap reconstruction at the Department of Orthopedic Surgery.ConclusionThe present case suggests that mammography findings of a tumor with coarse calcifications that are not typical of benign lesions may be extraskeletal osteosarcoma. A diagnosis must be made as early as possible in order to improve the prognosis of this disease.

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