A Case of Porocarcinoma From Pre-existing Hidroacanthoma Simplex: Need of Early Excision for Hidroacanthoma Simplex?

Abstract

There was no recurrence for 72 months after wide excision. CONCLUSION. : We recommend an early excision and careful attention in the case of HAS because of its potential malignant change.

Porocarcinoma Arising in Pigmented Hidroacanthoma Simplex

“…The gross appearance of malignant HAS tended to vary, and there were nodular lesions or keratotic plaques with or without erosion and/or ulceration. [4][5][6][7][8][9][10][11] In the present case, the porocarcinoma portion was erosive with depigmentation, and such a case has been reported previously. 3 Therefore, clinical findings such as erosion and/or ulceration and depigmentation might be indicative of the malignant transformation of HAS.…”

“…12 Malignant variants of HAS are rare and have been reported under different names, such as malignant HAS, in situ porocarcinoma, eccrine porocarcinoma, and HAS with invasive growth. [2][3][4][5][6][7][8][9][10][11] Most cases developed from pre-existing benign HAS, 3,5,7,11 as did our present case. In a review of the literature on malignant HAS, 6 the ages of patients ranged from 50 to 87 years, with the majority of patients being over 70 years of age.…”

“…2 Malignant HAS is extremely rare, and most of the reported cases have coexisted with HAS and, thus, represent the malignant transformation of pre-existing HAS. [3][4][5][6][7][8][9][10][11] In general, poroid neoplasms are believed to be of eccrine gland origin but poroid neoplasms are currently categorized as being of either eccrine or apocrine origin and, in particular, poroma with follicular and/or sebaceous differentiation is referred to as apocrine poroma. 12 Among a variety of cutaneous tumors, pigmentation and secondary amyloid deposition are found most frequently in basal cell carcinoma and seborrheic keratosis.…”

Hidroacanthoma simplex: A Case Report and Analysis of 70 Japanese Cases

“…Although it has been suggested that the course of most HS lesions is benign [8], some have been thought to have potential for malignant transformation [9,10]. An observation of atypical cells and mitotic cells in tumor nests, suggesting malignant transformation, was reported in 7 (10%) of 70 cases.…”

Eccrine porocarcinoma of the scalp

“…Mitoz ve tümör kalınlığının prognostik önemi bulunmadığını bildiren araştırıcılar da vardır (20). Duktal diferansiyasyon alanları CEA ve EMA immunohistokimyaları ile gösterilebilir (4,5,21). S100 ile neoplastik hücreler negatift ir (21,22,23).…”