A case of Pasteurella multocida peritoneal dialysis-associated peritonitis and review of the literature

Cooke, Fiona J.; Kodjo, Angéli; Clutterbuck, Elaine J.; Bamford, Kathleen B.

doi:10.1016/j.ijid.2003.10.004

Cited by 40 publications

(27 citation statements)

References 9 publications

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“…Among the Pasteurella species, P. multocida is the predominant human pathogen encountered, especially in severe disease cases (235,239), although P. canis may be more prevalent with dog bites (48, [246][247][248]. Common symptoms of pasteurellosis in humans from animal bite wounds are swelling (edema), cellulitis (diffuse, localized inflammation with redness and pain), and bloody or suppurative/ purulent exudate (drainage) at the wound site (39, 41, 48, 49, 160,165,241,[249][250][251][252][253][254][255]. Leukocyte and neutrophil counts are typically high at the infection site, and inflammation develops very rapidly.…”

Section: Pasteurella and Other Pasteurellaceae Diseases In Humans Pasmentioning

confidence: 99%

“…Patients with underlying diseases that contribute to an immunocompromised condition, such as cirrhosis (liver dysfunction) (39, 43, 241, 244, 249, 255-257, 260, 262, 263, 265, 266, 273, 275-280, 292, 312, 314, 316, 317, 321, 322, 328, 329, 335, 337, 345-359), renal failure (kidney dysfunction requiring dialysis or indwelling catheters) (253,267,300,302,303,318,324,326,327,(360)(361)(362)(363)(364)(365)(366), or HIV-positive status (especially if taking immunosuppressive drugs or experiencing other disease conditions) (290,310,315,(367)(368)(369), have an increased risk of peritonitis, endocarditis, and/or septicemia caused by P. multocida. This is particularly the case if there is a history of exposure to pets.…”

Section: Transmission and Prevalence Through Contact With Petsmentioning

confidence: 99%

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Pasteurella multocida: from Zoonosis to Cellular Microbiology

2013

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SUMMARY In a world where most emerging and reemerging infectious diseases are zoonotic in nature and our contacts with both domestic and wild animals abound, there is growing awareness of the potential for human acquisition of animal diseases. Like other Pasteurellaceae , Pasteurella species are highly prevalent among animal populations, where they are often found as part of the normal microbiota of the oral, nasopharyngeal, and upper respiratory tracts. Many Pasteurella species are opportunistic pathogens that can cause endemic disease and are associated increasingly with epizootic outbreaks. Zoonotic transmission to humans usually occurs through animal bites or contact with nasal secretions, with P. multocida being the most prevalent isolate observed in human infections. Here we review recent comparative genomics and molecular pathogenesis studies that have advanced our understanding of the multiple virulence mechanisms employed by Pasteurella species to establish acute and chronic infections. We also summarize efforts being explored to enhance our ability to rapidly and accurately identify and distinguish among clinical isolates and to control pasteurellosis by improved development of new vaccines and treatment regimens.

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Section: Pasteurella and Other Pasteurellaceae Diseases In Humans Pasmentioning

confidence: 99%

Section: Transmission and Prevalence Through Contact With Petsmentioning

confidence: 99%

Pasteurella multocida: from Zoonosis to Cellular Microbiology

2013

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“…PM0188 is a newly characterized sialyltransferase from Pasteurella multocida (subsP. multocida, strain PM70), which is a pathogen of livestock, poultry, wildlife, and laboratory rabbits and can cause pulmonary disease, sepsis, and meningitis (3). This enzyme plays important roles in cell-cell recognition, cell differentiation and various receptor-ligand interactions (4).…”

Section: Introductionmentioning

confidence: 99%

Structural analysis of sialyltransferase PM0188 from Pasteurella multocida complexed with donor analogue and acceptor sugar

et al. 2008

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PM0188 is a newly identified sialyltransferase from P. multocida which transfers sialic acid from cytidine 5'-monophosphonuraminic acid (CMP-NeuAc) to an acceptor sugar. Although sialyltransferases are involved in important biological functions like cell-cell recognition, cell differentiation and receptor-ligand interactions, little is known about their catalytic mechanism. Here, we report the X-ray crystal structures of PM0188 in the presence of an acceptor sugar and a donor sugar analogue, revealing the precise mechanism of sialic acid transfer. Site-directed mutagenesis, kinetic assays, and structural analysis show that Asp141, His311, Glu338, Ser355 and Ser356 are important catalytic residues; Asp141 is especially crucial as it acts as a general base. These complex structures provide insights into the mechanism of sialyltransferases and the structure-based design of specific inhibitors. [BMB reports 2008; 41(1): 48-54]

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“…multocida (hereafter referred to as P. multocida) is an economically important opportunistic pathogen of livestock (hemorrhagic septicemia, shipping fever, and atrophic rhinitis), poultry (fowl cholera), wildlife (avian cholera), and laboratory rabbits (snuffles) (1). As a commensal of cats and dogs, P. multocida also is a significant cause of zoonotic abscesses arising mainly from bites or scratches, but it has been increasingly associated with pulmonary disease, sepsis, and meningitis in patients with underlying medical conditions that may compromise their immune status (4,10,13,15,16,20,21,29,30,35,38,48). Although the so-called dermonecrotic toxin synthesized by some P. multocida strains produces atrophic rhinitis, the toxin is not essential for respiratory or systemic disease.…”

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confidence: 99%

Sialic Acid Metabolism and Systemic Pasteurellosis

et al. 2005

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Pasteurella multocida subsp. multocida is a commensal and opportunistic pathogen of food animals, wildlife, and pets and a zoonotic cause of human infection arising from contacts with these animals. Here, an investigation of multiple serotype A strains demonstrated the occurrence of membrane sialyltransferase. Although P. multocida lacks the genes for the two earliest steps in de novo sialic acid synthesis, adding sialic acid to the growth medium resulted in uptake, activation, and subsequent transfer of sialic acid to a membrane acceptor resembling lipooligosaccharide. Two candidate-activating enzymes with homology to Escherichia coli cytidine 5-monophospho-N-acetylneuraminate synthetase were overproduced as histidine-tagged polypeptides. The synthetase encoded by pm0187 was at least 37 times more active than the pm1710 gene product, suggesting pm0187 encodes the primary sialic acid cytidylyltransferase in P. multocida. A sialate aldolase (pm1715) mutant unable to initiate dissimilation of internalized sialic acid was not attenuated in the CD-1 mouse model of systemic pasteurellosis, indicating that the nutritional function of sialate catabolism is not required for systemic disease. In contrast, the attenuation of a sialate uptake-deficient mutant supports the essential role in pathogenesis of a sialylation mechanism that is dependent on an environmental (host) supply of sialic acid. The combined results provide the first direct evidence of sialylation by a precursor scavenging mechanism in pasteurellae and of a potential tripartite ATP-independent periplasmic sialate transporter in any species.

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A case of Pasteurella multocida peritoneal dialysis-associated peritonitis and review of the literature

Cited by 40 publications

References 9 publications

Pasteurella multocida: from Zoonosis to Cellular Microbiology

Pasteurella multocida: from Zoonosis to Cellular Microbiology

Structural analysis of sialyltransferase PM0188 from Pasteurella multocida complexed with donor analogue and acceptor sugar

Sialic Acid Metabolism and Systemic Pasteurellosis

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