A Case of New-Onset Lichen Planus after COVID-19 Vaccination

Abstract

The COVID 19 vaccination campaign has been underway for about a year now, and there are now many skin reactions associated with the administration of these vaccines in the literature. In view of the forthcoming third dose, we believe it is important to report our experience.

Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature

“…61 To date, 13 cases of new-onset cutaneous lichen planus and 3 cases of cutaneous lichen planus exacerbation have been reported. [62][63][64][65][66][67][68][69][70][71][72][73][74][75][76] Like psoriasis, also cases of new onset and flare of atopic dermatitis or eczema have been reported (7 and 14, respectively). [77][78][79][80][81][82][83] However, there is not a clear correlation with clinical phenotypes.…”

“… BNT162b2: 10 mRNA-1273: 3 AZD1222: 3 Ad26.COV2: 1 Flare of psoriasis 81 Huang et al 29 (15), Sotiriou et al 30 (14), Koumaki et al 31 (12), Megna et al 32 (11), Wei et al 53 (6), Ruggiero et al 26 (4), Durmaz et al 33 (2), Tran et al 34 (2), Piccolo et al 36 (2), Bostan et al 37 (1), Nagrani et al 35 (1), Pavia et al 38 (1), Durmus et al 39 (1), Fang et al 40 (1), Krajewski et al 41 (1), Trepanowski et al 42 (1), Mieczkowska et al 43 (1), Lopez et al 44 (1), Perna et al 45 (1), Tsunoda et al 47 (1), Nia et al 48 (1), Pesqué et al 28 (1). BNT162b2: 43 mRNA-1273: 17 AZD1222: 21 Ad26.COV2: 0 Cutaneous lichen planus 16 New-onset: Merhy et al 62 (1), Camela et al 63 (1), Kato et al 69 (1), Diab et al 70 (1), Zagaria et al 71 (1), Awada et al 72 (1), Picone et al 73 (1), Hlaca et al 74 (1), Zengarini et al 75 (1), Masseran et al 76 (1), Gamonal et al 64 (1), Alrawashdeh et al 65 (1), Shakoei et al 66 (1). Flare: Hiltun et al 67 (1), Herzum et al 68 (1), Hlaca et al 74 (1).…”

“…(1). Merhy et al62 (1), Camela et al63 (1), Kato et al69 (1), Diab et al70 (1), Zagaria et al71 (1), Awada et al72 (1), Picone et al73 (1), Hlaca et al74 (1), Zengarini et al75 (1), Masseran et al76 (1), Gamonal et al64 (1), Alrawashdeh et al65 (1), Shakoei et al66 (1). Zou et al122 (3), Gui et al123 (2), Rouatbi et al124 (2), Aryanian et al125 (1), Koutlas et al126 (1), Knechtl et al127 (1), Ong et al128 (1), Yıldırıcı et al129 (1), Singh et al130 (1), Norimatsu et al131 (1), Agharbi et al132 (1), Almasi-Nasrabadi et al133 (1),…”

Lichen planus related to COVID-19 vaccine: report of two cases.

“…The immune response is mediated by T helper lymphocytes type 1 (Th1) that produces an increase in TNF, interferon-gamma, and interleukin 2 [6][7][8][9].…”

Lichen planus pigmentosus inversus with nail involvement following COVID ‐19 vaccination: A case report

“… 5 However, data on the mechanism of action of COVID‐19 vaccines in the etiopathogenesis of lichen planus are inadequate. 9 …”