A Case of Neuromyelitis Optica With Gadolinium-Enhancing Brain Lesions and Parinaud Syndrome

Nystagmus and diplopia in a patient with positive aquaporin-4 antibody

“…Patients with NMOSD may manifest various ocular motor deficits in addition to classic characteristics of optic neuritis and transverse myelitis. The ocular motility abnormalities observed in NMOSD includes dorsal midbrain syndrome, 4,5 trochlear nerve palsy, 6,7 wall-eyed bilateral internuclear ophthalmoplegia syndrome, 8 ocular oscillations, 9 and restriction in extraocular movements such as that seen in our patient.…”

Nystagmus and diplopia in a patient with positive aquaporin-4 antibody

“…Patients with NMOSD may manifest various ocular motor deficits in addition to classic characteristics of optic neuritis and transverse myelitis. The ocular motility abnormalities observed in NMOSD includes dorsal midbrain syndrome, 4,5 trochlear nerve palsy, 6,7 wall-eyed bilateral internuclear ophthalmoplegia syndrome, 8 ocular oscillations, 9 and restriction in extraocular movements such as that seen in our patient.…”

Anti-aquaporin-4 antibody-positive dorsal midbrain syndrome

“…However, dorsal midbrain syndrome was mentioned only by Gilmore et al in correspondence, without detailed documentation. 2 Our patient did not have optic neuritis or longitudinal extensive transverse myelitis. Thus, a diagnosis of NMOSD was not suitable at that time.…”

“…However, dorsal midbrain syndrome was mentioned only by Gilmore et al in correspondence, without detailed documentation. 2…”

“…1 To our knowledge, the association between dorsal midbrain syndrome and neuromyelitis optica (NMO) has only been mentioned briefly in correspondence, without detailed documentation. 2 Here, we report a patient with dorsal midbrain syndrome related to the anti-aquaporin-4 (AQP4) antibody.…”

Neuromyelitis optica - an update: 2007-2009

“…They seem to predominate in areas with high AQP4 expression[26] [Figure 2]. The lesions are usually asymptomatic but may cause symptoms that may include lethargy, endocrine dysfunction, Parinaud syndrome,[27] hemiparesis, and coma. Large callosal lesions have been described in NMO.…”

Nystagmus and diplopia in a patient with positive aquaporin-4 antibody

“…Patients with NMOSD may manifest various ocular motor deficits in addition to classic characteristics of optic neuritis and transverse myelitis. The ocular motility abnormalities observed in NMOSD includes dorsal midbrain syndrome, 4,5 trochlear nerve palsy, 6,7 wall-eyed bilateral internuclear ophthalmoplegia syndrome, 8 ocular oscillations, 9 and restriction in extraocular movements such as that seen in our patient.…”

Anti-aquaporin-4 antibody-positive dorsal midbrain syndrome

“…However, dorsal midbrain syndrome was mentioned only by Gilmore et al in correspondence, without detailed documentation. 2 Our patient did not have optic neuritis or longitudinal extensive transverse myelitis. Thus, a diagnosis of NMOSD was not suitable at that time.…”

“…However, dorsal midbrain syndrome was mentioned only by Gilmore et al in correspondence, without detailed documentation. 2…”

“…1 To our knowledge, the association between dorsal midbrain syndrome and neuromyelitis optica (NMO) has only been mentioned briefly in correspondence, without detailed documentation. 2 Here, we report a patient with dorsal midbrain syndrome related to the anti-aquaporin-4 (AQP4) antibody.…”

Neuromyelitis optica - an update: 2007-2009

“…They seem to predominate in areas with high AQP4 expression[26] [Figure 2]. The lesions are usually asymptomatic but may cause symptoms that may include lethargy, endocrine dysfunction, Parinaud syndrome,[27] hemiparesis, and coma. Large callosal lesions have been described in NMO.…”

Nystagmus and diplopia in a patient with positive aquaporin-4 antibody

“…Patients with NMOSD may manifest various ocular motor deficits in addition to classic characteristics of optic neuritis and transverse myelitis. The ocular motility abnormalities observed in NMOSD includes dorsal midbrain syndrome, 4,5 trochlear nerve palsy, 6,7 wall-eyed bilateral internuclear ophthalmoplegia syndrome, 8 ocular oscillations, 9 and restriction in extraocular movements such as that seen in our patient.…”

Anti-aquaporin-4 antibody-positive dorsal midbrain syndrome

“…However, dorsal midbrain syndrome was mentioned only by Gilmore et al in correspondence, without detailed documentation. 2 Our patient did not have optic neuritis or longitudinal extensive transverse myelitis. Thus, a diagnosis of NMOSD was not suitable at that time.…”

“…However, dorsal midbrain syndrome was mentioned only by Gilmore et al in correspondence, without detailed documentation. 2…”

“…1 To our knowledge, the association between dorsal midbrain syndrome and neuromyelitis optica (NMO) has only been mentioned briefly in correspondence, without detailed documentation. 2 Here, we report a patient with dorsal midbrain syndrome related to the anti-aquaporin-4 (AQP4) antibody.…”

Neuromyelitis optica - an update: 2007-2009

“…They seem to predominate in areas with high AQP4 expression[26] [Figure 2]. The lesions are usually asymptomatic but may cause symptoms that may include lethargy, endocrine dysfunction, Parinaud syndrome,[27] hemiparesis, and coma. Large callosal lesions have been described in NMO.…”