A case of levetiracetam induced bullous pemphigoid

Abstract

Bullous pemphigoid is a chronic, acquired autoimmune skin disease. Certain drugs such as furosemide, penicillins, sulfonamides, ciprofloxacins, penicillamines, angiotensin converting enzyme inhibitors, chloroquine, and phenacetin were reported to cause bullous pemphigoid. This is a case report of a 70-year-old female, who presented with the formation of diffuse cutaneous blister in month after starting to use levetiracetam. Dermatological exam and histopathological findings were consistent with bullous pemphigoid. To the best of our knowledge this is the first case of bullous pemphigoid in the literature associated with levetiracetam use.

Intravenous levetiracetam of hospitalized patients in Srinagarind Hospital

“…Intravenous LEV use may be increased in the future. There are some reported side effects including Steven Johnson syndrome, bullous pemphigoid, and aggravation of myoclonus and non-convulsive SE (Isoda et al, 2012;Karadag et al, 2012;Liu et al, 2012;Zou et al, 2012). Rare conditions such as hypersexuality are also reported after LEV use (Metin et al, 2012).…”

Levetiracetam-induced leukocytoclastic vasculitis

“…[9] Cutaneous side effects with levetiracetam are less frequent compared to other antiepileptic medication, but adverse effects such as bullous pemphigoid, maculopapular drug rash, and drug reaction with eosinophilia and systemic symptoms have been reported. [10] Even though LCV is a common adverse effect of antiepileptics, but to the best of our knowledge, this is the first reported case of LCV with levetiracetam. Based on time–event relationship, morphology, distribution, histopathological findings, and rapid response on withdrawal of the drug, we conclude that patient developed LCV due to levetiracetam.…”

A Rare Skin Manifestation in a Patient With Human Immunodeficiency Virus: A Case Report and Review of the Literature

“…Karadag and colleagues reported a case of a 70-year-old female who developed BP 1 month after starting to use levetiracetam [15]. Our patient was treated with levetiracetam for the past 6 months before presenting with skin blisters.…”