A case of immune reconstitution inflammatory syndrome related to a disseminated histoplasmosis in an HIV-1 infected patient

Mambie, A.; Pasquet, A.; Melliez, H.; Bonne, Severine; Blanc, Anne-Laure; Patoz, P.; Ajana, F.

doi:10.1097/01.aids.0000432448.53110.e3

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Progressive disseminated histoplasmosis (PDH) was diagnosed in 102 of the 114 cases (89.5%); the remaining 12 patients presented with colonic or small bowel involvement (6 cases, 5.3%) [17,18,21,31,34,68], lymph node involvement (2 cases, 1.8%) [24,28], and there was one case each of primary cutaneous [39], cerebral [64], pulmonary [36] or vaginal histoplasmosis [35]. Eight cases of immune reconstitution inflammatory syndrome (IRIS) were diagnosed following antiretroviral treatment [26,29,48,57,59], three patients had haemophagocytic syndrome [27,30,59], and one presented with posterior reversible encephalopathy syndrome (PRESS) [54]. Concomitant opportunistic infections and/or neoplasia were observed in 28.3% of the patients at the time of the diagnosis of histoplasmosis (Table 2 [23,50,51,69], two disseminated cryptococcosis [18,52], and one pulmonary coccidioidomycosis [22].…”

Section: People Living With Hiv (Plwh)mentioning

confidence: 99%

Histoplasmosis Diagnosed in Europe and Israel: A Case Report and Systematic Review of the Literature from 2005 to 2020

Antinori

Giacomelli

Corbellino

et al. 2021

JoF

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Human histoplasmosis is a mycosis caused by two distinct varieties of a dimorphic fungus: Histoplasma capsulatum var. capsulatum and H. capsulatum var. duboisii. In Europe, it is usually imported by migrants and travellers, although there have been some autochthonous cases, especially in Italy; however, most European physicians are unfamiliar with its clinical and pathological picture, particularly among immunocompromised patients without HIV infection. This systematic review of all the cases of histoplasmosis reported in Europe and Israel between 2005 and 2020 identified 728 cases diagnosed in 17 European countries and Israel described in 133 articles. The vast majority were imported (mainly from Central and South America), but there were also seven autochthonous cases (six in Europe and one in Israel). The patients were prevalently males (60.4%), and their ages ranged from 2 to 86 years. The time between leaving an endemic region and the diagnosis of histoplasmosis varied from a few weeks to more than 40 years. Progressive disseminated histoplasmosis was the most frequent clinical picture among people living with HIV infection (89.5%) or a different immunocompromising condition (57.1%), but it was also recorded in 6.2% of immunocompetent patients. Twenty-eight cases were caused by Histoplasma duboisii. Immunocompromised patients without HIV infection had the worst outcomes, with a mortality rate of 32%.

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Section: People Living With Hiv (Plwh)mentioning

confidence: 99%

Histoplasmosis Diagnosed in Europe and Israel: A Case Report and Systematic Review of the Literature from 2005 to 2020

Antinori

Giacomelli

Corbellino

et al. 2021

JoF

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“… 38 Other less common manifestations of PDH include endocrine syndromes, such as chronic adrenal insufficiency, 39 and myositis, of which only 4 cases were reported so far. 40 In AIDS patients from endemic areas starting cART, a few cases of immune reconstitution inflammatory syndrome (IRIS) revealing PDH have been described: fever, weight loss, and lymphadenitis were the main symptoms in these reports. 41 …”

Section: Clinical Featuresmentioning

confidence: 99%

Disseminated Histoplasmosis as Aids Presentation. Case Report and Comprehensive Review of Current Literature

Zanotti

Chirico

Gulletta

et al. 2018

Mediterr J Hematol Infect Dis

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Progressive disseminated histoplasmosis (PDH) is an AIDS-defining illness with a high lethality rate if not promptly treated. The wide range of its possible clinical manifestations represents the main barrier to diagnosis in non-endemic countries. Here we present a case of PDH with haemophagocytic syndrome in a newly diagnosed HIV patient and a comprehensive review of disseminated histoplasmosis focused on epidemiology, clinical features, diagnostic tools and treatment options in HIV-infected patients.

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Incidence and Trends in Immune Reconstitution Inflammatory Syndrome Associated With Histoplasma capsulatum Among People Living With Human Immunodeficiency Virus: A 20-Year Case Series and Literature Review

Melzani¹,

Michel²,

Ntab

et al. 2019

Clinical Infectious Diseases

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A case of immune reconstitution inflammatory syndrome related to a disseminated histoplasmosis in an HIV-1 infected patient

Cited by 3 publications

References 6 publications

Histoplasmosis Diagnosed in Europe and Israel: A Case Report and Systematic Review of the Literature from 2005 to 2020

Histoplasmosis Diagnosed in Europe and Israel: A Case Report and Systematic Review of the Literature from 2005 to 2020

Disseminated Histoplasmosis as Aids Presentation. Case Report and Comprehensive Review of Current Literature

Incidence and Trends in Immune Reconstitution Inflammatory Syndrome Associated With Histoplasma capsulatum Among People Living With Human Immunodeficiency Virus: A 20-Year Case Series and Literature Review

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