A Case of Hidroacanthoma Simplex

Suh, Ho Seok; Lee, Hwa Jung; Kim, Hyun Su; Choi, Jee Ho; Sung, Kyung Jeh; Moon, Kee Chan; Koh, Jai‐Kyoung

doi:10.1111/j.1346-8138.1997.tb02316.x

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…A previous immunohistochemical study 11 of cytokeratins in HS showed a negative reaction for 35 β H11 (CK8) and 35 β E12 (CK1, 5, 10 and 11). Our study clearly showed the presence in HS of CK14 and 17, and the absence in HS of CK1, 10 and 19.…”

Section: Cytokeratin Expression In the Acrosyringium Intradermal Ducmentioning

confidence: 80%

A case report of hidroacanthoma simplex with an immunohistochemical study of cytokeratins

et al. 2004

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Dear Sir,The origin of hidroacanthoma simplex (HS) is not yet clear. We report a case of HS in which the expression of cytokeratin (CK) was studied immunohistochemically using seven antikeratin antibodies. CK expression in HS has not been studied in detail before.HS, which was first described by Smith and Coburn, 1 is confined to the epidermis, and is recognized as intraepidermal eccrine poroma. An electron microscope study 2 found that tumor cells are identical to the outer layer of the intraepidermal eccrine duct. CK is a useful marker for investigating the origin of epithelial tumors. 3 Monospecific antikeratin antibodies may make it possible to clarify the origin and the differentiation of epithelial tumors. Histopathologically, HS arises from the lower portion of the epidermis, and extends downward into the dermis.The patient in this case was a 41-year-old woman. HS was located on her buttock. A sample was surgically excised, and the excised specimen was cut into sections of 4 µ m thickness, fixed in formalin, and embedded in paraffin. The sections were stained with hematoxylin and eosin for histopathologic examination. The antikeratin antibodies used here were 34 β B4 (Immunohistochemical procedures were performed using the labeled streptoavidin-biotin method, as reported previously. 8 Hematoxylin and eosin sections showed tumor nests with small basaloid cells in the epidermis. The border between the epidermis and the tumor was well defined.Cytokeratin expression in the normal epidermal eccrine sweat gland was investigated in previous reports. 9,10 The same staining patterns were observed in normal eccrine ducts in the sample. In HS, CK1 (Fig. 1) and CK10 were not present in the tumor cells. CK8 and 18 were also absent from the tumor cells. The tumor cells were positive for CK14, and strongly positive for CK17 (Fig. 2). CK19 was not found in the tumor cells.A previous immunohistochemical study 11 of cytokeratins in HS showed a negative reaction for 35 β H11 (CK8) and 35 β E12 (CK1, 5, 10 and 11). Our study clearly showed the presence in HS of CK14 and 17, and the absence in HS of CK1, 10 and 19. In the outer and inner cells of the acrosyringium, CK1 and 10 were present, and CK14 and 17 were absent. CK19 was present in the inner cells of the acrosyringium and intradermal ducts (Table 1). Our immunohistochemical study therefore shows that CK expression in HS has a different immunophenotype (characteristic) from that in acrosyringial cells. The presence of CK17 in HS implies that the tumor cells are in a hyperproliferative state, and the presence of CK14 Figure 1 The suprabasal layers in the epidermis are positive for CK1, but CK1 was not present in tumor cells (immunohistochemical stain, ×100)

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Section: Cytokeratin Expression In the Acrosyringium Intradermal Ducmentioning

confidence: 80%

A case report of hidroacanthoma simplex with an immunohistochemical study of cytokeratins

et al. 2004

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“…Hidroacanthoma simplex is a rare skin tumor described as verrucous keratotic plaque clinically resembling seborrheic keratosis or Bowen's disease. 11,12 The tumor often occurs on lower extremities and trunk of elderly persons. In our study, all three cases also arose on extremities, which was compatible with the previous studies.…”

Section: Discussionmentioning

confidence: 99%

Clinical and histological characteristics of poroid neoplasms: a study of 25 cases in Taiwan

2006

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“…Immunostaining with carcinoembryonic antigen, epithelial membrane antigen and antikeratin antibodies seems to be not helpful in diagnosing HS [5]. However, some interesting variety of findings on immunostaining with antikeratin antibodies has been reported [5][6][7]. Electron microscopy has been reported to be helpful in diagnosing HS [5].…”

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confidence: 99%