A case of drug-induced eosinophilic pneumonia possibly associated with mesalazine

Mesalazine-induced lung injury with severe respiratory failure successfully treated with steroids and non-invasive positive pressure ventilation

“…We present a case of mesalazine-induced lung injury with severe respiratory failure and a confirmed histological pattern of organizing pneumonia that was successfully treated with discontinuation of mesalazine and provision of steroid pulse therapy and NPPV. Almost all UC patients with mesalazine-induced lung injury in the literature review showed mild or no respiratory failure, which was improved only by discontinuation of the drug or administration of low-dose corticosteroids [ [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] ] ( Table 1 ).…”

“…Mesalazine, also known as 5-aminosalicylic acid (5-ASA), is the first-line treatment for patients with mild-to-moderate ulcerative colitis (UC), and it has been reported to be a causative agent for drug-induced lung injury (DLI) [ [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] ] ( Table 1 ). Although several cases of mesalazine-induced lung injury have been reported, only one case has so far been reported of severe respiratory failure in which mechanical ventilation was used [ 20 ].…”